Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 822930..823508 Replicon chromosome
Accession NZ_CP010802
Organism Desulfuromonas soudanensis strain WTL

Toxin (Protein)


Gene name mazF Uniprot ID A0A0M4DFZ9
Locus tag DSOUD_RS03475 Protein ID WP_053549695.1
Coordinates 823176..823508 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0M5IYL1
Locus tag DSOUD_RS03470 Protein ID WP_053552278.1
Coordinates 822930..823175 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSOUD_RS18295 818135..819853 + 1719 WP_157671734.1 hypothetical protein -
DSOUD_RS03465 820443..822728 + 2286 WP_053549694.1 hypothetical protein -
DSOUD_RS03470 822930..823175 + 246 WP_053552278.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DSOUD_RS03475 823176..823508 + 333 WP_053549695.1 endoribonuclease MazF Toxin
DSOUD_RS03480 823599..823931 - 333 WP_053549696.1 DUF86 domain-containing protein -
DSOUD_RS03485 823928..824212 - 285 WP_053549697.1 nucleotidyltransferase family protein -
DSOUD_RS03490 824421..826334 - 1914 WP_053549698.1 biosynthetic arginine decarboxylase -
DSOUD_RS03495 826607..827455 - 849 WP_053549699.1 polyamine aminopropyltransferase -
DSOUD_RS03500 827641..828114 - 474 WP_053549700.1 arginine decarboxylase, pyruvoyl-dependent -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-107)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12033.11 Da        Isoelectric Point: 9.5418

>T52867 WP_053549695.1 NZ_CP010802:823176-823508 [Desulfuromonas soudanensis]
VGYIPNRGDVVWLLFDPQAGHEQSGHRLALVLSPLKYNKLTSLMLCCPLTSAIKGYPFEVATTVNEKAGVILADQVKSLD
WRARKAKKAGIVTQSVLEETLAKIETLLKG

Download         Length: 333 bp

>T52867 NZ_CP010802:823176-823508 [Desulfuromonas soudanensis]
GTGGGCTATATTCCGAACCGGGGTGATGTGGTGTGGTTGCTTTTTGATCCGCAGGCCGGGCATGAACAGTCGGGCCATCG
ACTCGCGTTGGTGCTGTCACCTCTGAAGTACAACAAGCTCACCAGTTTGATGCTCTGCTGCCCCCTGACAAGTGCAATCA
AAGGGTATCCTTTCGAGGTGGCGACAACCGTAAACGAAAAGGCTGGCGTCATCCTCGCCGATCAGGTAAAAAGCCTTGAC
TGGCGGGCTCGCAAGGCAAAAAAAGCAGGGATCGTTACTCAATCCGTGCTCGAAGAGACACTCGCCAAAATAGAGACTCT
TTTGAAGGGATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8978.19 Da        Isoelectric Point: 4.7553

>AT52867 WP_053552278.1 NZ_CP010802:822930-823175 [Desulfuromonas soudanensis]
VLAKVQKWGNSLALRLPKALADEADVHLDSPVEITVRDHTICIQPLRQKEIFDLDDLLAGVTSDNLHGETDSVHPVGKEV
W

Download         Length: 246 bp

>AT52867 NZ_CP010802:822930-823175 [Desulfuromonas soudanensis]
GTGCTTGCAAAAGTACAGAAATGGGGGAATAGCCTGGCTCTGCGCCTGCCGAAAGCGTTGGCTGACGAAGCCGATGTTCA
TCTTGATTCGCCTGTGGAAATTACCGTCCGCGACCATACCATTTGCATACAGCCTCTGCGTCAAAAAGAGATATTCGACC
TCGATGATCTGCTGGCCGGGGTGACATCGGACAATCTTCACGGCGAGACGGACTCTGTCCATCCGGTCGGCAAGGAGGTT
TGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4DFZ9

Antitoxin

Source ID Structure
AlphaFold DB A0A0M5IYL1

References