Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 619814..620339 Replicon chromosome
Accession NZ_CP010802
Organism Desulfuromonas soudanensis strain WTL

Toxin (Protein)


Gene name relE Uniprot ID A0A0M4CYB2
Locus tag DSOUD_RS02645 Protein ID WP_053549546.1
Coordinates 619814..620104 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0M4CUS6
Locus tag DSOUD_RS02650 Protein ID WP_053549547.1
Coordinates 620094..620339 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSOUD_RS17675 615781..616233 + 453 WP_082351028.1 DNA mismatch endonuclease Vsr -
DSOUD_RS17680 616235..617476 + 1242 WP_082351029.1 type II restriction endonuclease -
DSOUD_RS02620 617662..617886 + 225 WP_053549542.1 hypothetical protein -
DSOUD_RS02625 617976..618170 + 195 WP_053549543.1 hypothetical protein -
DSOUD_RS02630 618694..618951 + 258 WP_053552266.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
DSOUD_RS02635 618955..619233 + 279 WP_053549544.1 type II toxin-antitoxin system RelE/ParE family toxin -
DSOUD_RS02640 619307..619516 + 210 WP_053549545.1 hypothetical protein -
DSOUD_RS02645 619814..620104 - 291 WP_053549546.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DSOUD_RS02650 620094..620339 - 246 WP_053549547.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
DSOUD_RS02660 620629..621297 - 669 WP_053549549.1 hypothetical protein -
DSOUD_RS02665 621386..622561 - 1176 WP_053552267.1 glycoside hydrolase -
DSOUD_RS02670 622692..624101 - 1410 WP_053549550.1 formate dehydrogenase accessory sulfurtransferase FdhD -
DSOUD_RS02675 624115..624966 - 852 WP_053549551.1 formate dehydrogenase accessory protein FdhE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 613209..621297 8088


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-64)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11165.23 Da        Isoelectric Point: 10.6465

>T52866 WP_053549546.1 NZ_CP010802:c620104-619814 [Desulfuromonas soudanensis]
MTFNLEFKESALKEWKKLDGTIREQFKKKLAERLVRPCVESSRLKGMADCYKIKLKNAGYRLVYQVDNSRVVVIVVAVGK
RENLTVYKVAGKRVRE

Download         Length: 291 bp

>T52866 NZ_CP010802:c620104-619814 [Desulfuromonas soudanensis]
ATGACCTTTAACCTCGAATTCAAGGAATCGGCGCTGAAGGAGTGGAAGAAGCTCGATGGGACGATCCGTGAACAGTTCAA
GAAGAAGCTTGCCGAGCGCCTGGTCCGGCCGTGTGTCGAATCTTCCCGGCTCAAGGGAATGGCCGACTGCTATAAGATCA
AACTGAAAAATGCCGGCTATCGGCTGGTTTATCAGGTAGATAACAGCCGGGTGGTGGTCATCGTCGTGGCGGTGGGAAAG
CGGGAGAATCTGACGGTGTACAAGGTGGCGGGTAAGCGGGTGAGGGAGTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9122.38 Da        Isoelectric Point: 4.6631

>AT52866 WP_053549547.1 NZ_CP010802:c620339-620094 [Desulfuromonas soudanensis]
MERLYARASVSISDLKKNPSRIIHEAEGTPVAILNHNKPSAYLVPAEAFEALMEKLEDYELSRIVKERESEPTVPVSLDD
L

Download         Length: 246 bp

>AT52866 NZ_CP010802:c620339-620094 [Desulfuromonas soudanensis]
ATGGAACGTCTTTATGCCCGCGCCTCCGTCAGTATCAGCGACCTGAAGAAAAATCCTTCTCGAATCATCCATGAAGCAGA
GGGGACCCCCGTCGCGATTCTGAACCACAATAAACCCAGCGCCTATCTCGTCCCCGCCGAGGCTTTCGAGGCCCTCATGG
AAAAGCTCGAAGACTACGAGCTCTCCCGCATCGTCAAAGAGCGGGAGAGTGAACCGACTGTGCCGGTTTCCCTCGATGAC
CTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4CYB2

Antitoxin

Source ID Structure
AlphaFold DB A0A0M4CUS6

References