Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 125149..126892 Replicon chromosome
Accession NZ_CP010800
Organism Ralstonia mannitolilytica strain SN82F48

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag TK49_RS17110 Protein ID WP_045218378.1
Coordinates 125990..126892 (-) Length 301 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2N5L7K0
Locus tag TK49_RS17105 Protein ID WP_045218376.1
Coordinates 125149..125976 (-) Length 276 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TK49_RS17085 120309..121790 - 1482 WP_045218360.1 aldehyde dehydrogenase -
TK49_RS17090 121799..122602 - 804 WP_045218362.1 aspartate dehydrogenase -
TK49_RS17095 122635..124350 - 1716 WP_045218364.1 thiamine pyrophosphate-binding protein -
TK49_RS17100 124343..125146 - 804 WP_045218373.1 SDR family oxidoreductase -
TK49_RS17105 125149..125976 - 828 WP_045218376.1 IclR family transcriptional regulator Antitoxin
TK49_RS17110 125990..126892 - 903 WP_045218378.1 alpha/beta hydrolase Toxin
TK49_RS17115 126897..127433 - 537 WP_045218380.1 cupin domain-containing protein -
TK49_RS17120 127484..128257 - 774 WP_045218382.1 SDR family oxidoreductase -
TK49_RS17125 128250..129317 - 1068 WP_045218384.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
TK49_RS17130 129399..129716 - 318 WP_045218385.1 hypothetical protein -
TK49_RS17135 129923..130384 - 462 WP_045218388.1 GNAT family N-acetyltransferase -
TK49_RS17140 130707..130946 - 240 WP_045218390.1 DUF2798 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-288)

Antitoxin

Transcription regulator IclR, N-terminal

(19-68)


Sequences

Toxin        


Download         Length: 301 a.a.        Molecular weight: 32056.34 Da        Isoelectric Point: 6.8322

>T52863 WP_045218378.1 NZ_CP010800:c126892-125990 [Ralstonia mannitolilytica]
MSAQAAMSSRPFRVADALAVLEAEFAERSVTINAQRDRIGYRQWGGRGPVVVLLHGISSSAASWLPCAQVLSHTMRVFAW
DAPGYGRSTPLEQAEPRAADYAVRLQAWLDALQVKPDVIVGHSLGALMAAAYVAQAPEALQPGCVLLLNPAQGYGQPGHE
DQSRSVRAQRLATLDRLGIEGMAESRHAHLLRPDAGSEERAWVRWNMLRLNDAGYRQAVVMLSGDDIGAYLRKRPASTPA
RVACGDVDGITPPQGCEALADAFGLPFARVTAAGHASYIDAPDAVAGWIAQAAFSPLQNA

Download         Length: 903 bp

>T52863 NZ_CP010800:c126892-125990 [Ralstonia mannitolilytica]
ATGAGCGCGCAGGCTGCCATGTCTTCCCGTCCGTTTCGCGTGGCCGATGCACTGGCCGTGCTCGAGGCCGAGTTTGCCGA
ACGCAGCGTCACGATCAACGCCCAGCGCGATCGCATCGGCTATCGGCAGTGGGGCGGTCGCGGGCCGGTGGTGGTGCTGT
TGCACGGCATCAGCTCCAGCGCCGCGTCGTGGCTGCCTTGCGCGCAGGTTCTCTCCCACACCATGCGCGTGTTCGCGTGG
GATGCGCCGGGCTATGGCCGATCCACGCCGCTCGAACAAGCCGAGCCGCGCGCTGCCGATTACGCGGTGCGCCTGCAGGC
ATGGCTGGACGCGCTGCAGGTGAAGCCGGACGTGATCGTCGGACATTCGCTGGGCGCGCTGATGGCTGCGGCCTATGTGG
CGCAGGCGCCGGAAGCGCTGCAACCCGGCTGCGTGCTGCTGCTGAATCCCGCGCAGGGTTACGGGCAGCCCGGTCACGAA
GACCAGTCCCGCAGTGTGCGGGCCCAGCGCCTTGCCACGCTCGACCGGCTTGGTATCGAGGGCATGGCGGAATCGCGCCA
CGCGCATCTGCTGCGCCCGGATGCCGGCAGCGAAGAGCGCGCCTGGGTGCGCTGGAACATGCTGCGCCTGAACGACGCCG
GTTACCGCCAGGCCGTGGTCATGCTCAGCGGCGACGACATCGGCGCGTATCTGCGCAAGCGCCCCGCCTCAACGCCCGCT
CGCGTGGCCTGTGGCGATGTCGACGGCATCACGCCCCCGCAGGGCTGCGAAGCGTTGGCCGACGCCTTCGGCCTGCCTTT
CGCGCGGGTGACCGCCGCCGGGCACGCGTCGTACATCGATGCGCCGGATGCCGTTGCCGGCTGGATCGCGCAAGCCGCTT
TCTCCCCACTCCAAAACGCCTAA

Antitoxin


Download         Length: 276 a.a.        Molecular weight: 30656.37 Da        Isoelectric Point: 5.2423

>AT52863 WP_045218376.1 NZ_CP010800:c125976-125149 [Ralstonia mannitolilytica]
MSNDLIPEDVQEKYIVPGLERGLRLLCEFSHKDRVLSAPELARRLKVPRSTVFRLLTTLEVMGFIERVDGGRDFRLGMAV
LRLGFEYLASLELTELGRPLLDRLRDDIHYPCNLVVRDGRSIVYVAKSVAPTPFTSSVNVGTRLPAHATVLGRVLLADLS
LAELRQLYPEPQLEAFTANTPRTVEDLFEMVQRDREHGYVLEEGFFEANISTIAAPVLDRAGKIVAALGTTIPSPRIDPA
QLDPMIDKVRAAADELSYLLDYRPASGKVVNLFGE

Download         Length: 828 bp

>AT52863 NZ_CP010800:c125976-125149 [Ralstonia mannitolilytica]
ATGAGCAACGACCTCATTCCCGAAGACGTGCAGGAAAAGTACATCGTGCCCGGGCTCGAACGCGGCCTGCGCCTGCTGTG
CGAGTTCAGCCACAAAGACCGCGTGCTGTCTGCGCCGGAACTGGCGCGCCGGCTGAAGGTGCCGCGCTCCACGGTGTTCC
GCCTGCTGACCACGCTCGAGGTGATGGGCTTCATCGAACGCGTGGACGGCGGCCGGGATTTCCGCCTCGGCATGGCCGTG
CTGCGCCTCGGGTTCGAATATCTCGCCTCGCTCGAGTTGACCGAACTTGGCCGTCCGCTGCTCGACCGCCTGCGCGACGA
CATTCACTATCCGTGCAACCTTGTCGTGCGCGATGGCCGCTCGATCGTCTACGTGGCGAAATCGGTGGCGCCGACGCCGT
TCACGAGTTCGGTCAACGTCGGTACGCGCCTGCCCGCGCACGCCACGGTGCTGGGGCGCGTGCTGCTGGCAGACCTGTCG
CTGGCCGAGCTGCGCCAGCTGTATCCGGAGCCGCAGCTGGAGGCATTCACCGCCAACACGCCGCGCACCGTGGAAGACCT
GTTCGAGATGGTGCAGCGCGACCGCGAACACGGCTACGTGCTCGAAGAGGGCTTCTTCGAGGCCAACATCTCGACGATCG
CGGCGCCGGTGCTCGACCGCGCCGGCAAGATCGTCGCCGCCCTCGGTACGACGATCCCGTCGCCGCGCATCGACCCCGCG
CAGCTCGATCCCATGATCGACAAGGTGCGCGCCGCCGCAGACGAGCTCTCTTACCTGCTCGACTACCGCCCGGCCAGCGG
CAAGGTTGTCAACCTGTTCGGGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2N5L7K0

References