Detailed information of TA system TA052862

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ImmA-IrrE/Peptidase_M78-HTH_26
• Location: 73445..74120
• Replicon: chromosome
• Accession: NZ_CP010796
• Organism: Carnobacterium sp. CP1

Toxin (Protein)

• Gene name: IrrE
• Uniprot ID: A0A0U3MJN0
• Locus tag: NY10_RS00395
• Protein ID: WP_058918128.1
• Coordinates: 73445..73789 (-)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: ImmA
• Uniprot ID: A0A0U3PKC0
• Locus tag: NY10_RS00400
• Protein ID: WP_058918129.1
• Coordinates: 73800..74120 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NY10_RS00365	68969..69148	+	180	WP_058918122.1	50S ribosomal protein L32	-
NY10_RS00370	69284..70456	-	1173	WP_197408969.1	site-specific integrase	-
NY10_RS00375	70586..71248	-	663	WP_058918124.1	hypothetical protein	-
NY10_RS00380	71248..71646	-	399	WP_058918125.1	hypothetical protein	-
NY10_RS00385	71639..72604	-	966	WP_058918126.1	AAA family ATPase	-
NY10_RS00390	72709..73239	-	531	WP_058918127.1	PH domain-containing protein	-
NY10_RS00395	73445..73789	-	345	WP_058918128.1	ImmA/IrrE family metallo-endopeptidase	Toxin
NY10_RS00400	73800..74120	-	321	WP_058918129.1	helix-turn-helix domain-containing protein	Antitoxin
NY10_RS00405	74398..74592	+	195	WP_058918130.1	helix-turn-helix transcriptional regulator	-
NY10_RS00410	74593..75312	+	720	WP_058918131.1	ORF6C domain-containing protein	-
NY10_RS00415	75315..75575	+	261	WP_058918132.1	hypothetical protein	-
NY10_RS00420	75852..76136	+	285	WP_058918133.1	hypothetical protein	-
NY10_RS00425	76149..76334	+	186	WP_058918134.1	hypothetical protein	-
NY10_RS00430	76345..76551	+	207	WP_058918135.1	hypothetical protein	-
NY10_RS00435	76605..78620	+	2016	WP_058918136.1	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	69284..116331	47047

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• IrrE N-terminal-like domain (27-89)

Antitoxin

• Cro/C1-type helix-turn-helix domain (5-59)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 13417.25 Da
• Isoelectric Point: 4.2511

>T52862 WP_058918128.1 NZ_CP010796:c73789-73445 [Carnobacterium sp. CP1]
MDIMFDLLEENGIELVLINLEKNGYYNPVLKTMFVNQALDEEDQKEVILHELGHALNHNDISVLYDQPVFKFKMENEATS
FMMNHLIKEYDGHFNYSDVLENYNLGLGWECKLK

Nucleotide

• Length: 345 bp

>T52862 NZ_CP010796:c73789-73445 [Carnobacterium sp. CP1]
ATGGATATCATGTTTGATTTACTCGAGGAAAACGGGATTGAACTTGTATTGATAAACCTTGAAAAGAATGGGTACTATAA
TCCAGTCTTAAAAACGATGTTTGTTAATCAAGCCTTAGATGAAGAAGATCAAAAAGAAGTTATACTTCACGAATTAGGCC
ATGCTTTAAATCATAACGATATATCAGTCTTATACGATCAACCTGTATTTAAATTTAAAATGGAAAATGAAGCTACTTCT
TTTATGATGAATCACTTGATCAAGGAATATGACGGTCACTTTAATTATTCCGATGTCTTAGAGAACTATAATTTAGGATT
AGGTTGGGAGTGCAAATTAAAATAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12274.87 Da
• Isoelectric Point: 4.9860

>AT52862 WP_058918129.1 NZ_CP010796:c74120-73800 [Carnobacterium sp. CP1]
MGIVDRIKELCEIHHTNFAEVERRVGISNGQIRRWDNASPKLENIEKVADYFGVTVDYLRGKDPEEKLPTDLDKILDNMM
SFDGKPMTENDREAIRAYLEGRFSSK

Nucleotide

• Length: 321 bp

>AT52862 NZ_CP010796:c74120-73800 [Carnobacterium sp. CP1]
ATGGGAATAGTAGATAGAATAAAAGAGTTATGCGAAATTCATCACACTAATTTTGCTGAGGTCGAGAGGCGTGTTGGTAT
TTCTAACGGACAAATCAGAAGGTGGGATAATGCTTCACCTAAGCTAGAGAACATAGAAAAAGTGGCTGATTACTTCGGTG
TTACAGTTGACTATTTACGCGGGAAAGATCCTGAAGAAAAACTCCCTACTGATCTTGATAAGATATTAGATAATATGATG
AGCTTTGATGGAAAACCTATGACCGAAAATGATAGAGAAGCAATTCGTGCTTATCTTGAAGGAAGATTCAGCAGCAAGTA
A

Structures

Toxin

• AlphaFold DB: A0A0U3MJN0

Antitoxin

• AlphaFold DB: A0A0U3PKC0