Detailed information of TA system TA052854

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 10218..10779
• Replicon: plasmid pP88_b
• Accession: NZ_CP010727
• Organism: Phaeobacter inhibens strain P88

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A917AH87
• Locus tag: PhaeoP88_RS19565
• Protein ID: WP_071974127.1
• Coordinates: 10504..10779 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1N7QLX2
• Locus tag: PhaeoP88_RS19560
• Protein ID: WP_044353023.1
• Coordinates: 10218..10517 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PhaeoP88_RS19535	5254..6192	+	939	WP_090525075.1	DUF1738 domain-containing protein	-
PhaeoP88_RS19540	6263..6652	+	390	WP_090525076.1	DUF3768 domain-containing protein	-
PhaeoP88_RS19545	6808..8790	+	1983	WP_090525078.1	ParB/RepB/Spo0J family partition protein	-
PhaeoP88_RS19550	8864..9457	+	594	WP_090525080.1	regulator	-
PhaeoP88_RS19555	9457..10113	+	657	WP_090525082.1	hypothetical protein	-
PhaeoP88_RS19560	10218..10517	+	300	WP_044353023.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
PhaeoP88_RS19565	10504..10779	+	276	WP_071974127.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
PhaeoP88_RS19570	10887..15149	+	4263	WP_102884476.1	strawberry notch family protein	-
PhaeoP88_RS19575	15271..15657	+	387	WP_090525086.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..214690	214690

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-54)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10388.92 Da
• Isoelectric Point: 4.5837

>T52854 WP_071974127.1 NZ_CP010727:10504-10779 [Phaeobacter inhibens]
MPNLEWKATAIADLLAIIDYISDDNPDAAQVLKDEIEHKTSLLPERPQMYRAGRVDGTREMVVRPNYIVVYAESPEMVTI
LRVLHAAQQWP

Nucleotide

• Length: 276 bp

>T52854 NZ_CP010727:10504-10779 [Phaeobacter inhibens]
TTGCCAAATCTTGAATGGAAAGCCACGGCCATAGCCGACTTGCTGGCAATCATTGACTACATCTCTGACGACAACCCGGA
TGCCGCCCAAGTTCTCAAAGACGAGATTGAACACAAGACGTCCCTCCTTCCAGAACGCCCTCAGATGTACCGCGCGGGCC
GTGTGGACGGGACTAGGGAGATGGTTGTTCGGCCGAACTACATCGTGGTTTATGCTGAAAGCCCTGAGATGGTGACCATT
TTGCGCGTTCTTCATGCTGCGCAGCAGTGGCCATGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10462.91 Da
• Isoelectric Point: 5.6448

>AT52854 WP_044353023.1 NZ_CP010727:10218-10517 [Phaeobacter inhibens]
MPAQTSMLHVRVDDQLKAQASDALAGVGLTLSDAVRILLTRVAAEGGLPAGLTADPDAYDAWFRAKVQEALDDPRPTTPH
AKAMQDAQALIDGKRLAKS

Nucleotide

• Length: 300 bp

>AT52854 NZ_CP010727:10218-10517 [Phaeobacter inhibens]
ATGCCTGCCCAAACATCCATGCTTCATGTCCGTGTTGACGATCAGCTGAAAGCACAGGCTTCGGACGCACTTGCGGGCGT
CGGTCTGACGCTCTCCGACGCGGTGCGTATTCTTCTGACCCGCGTGGCCGCAGAAGGCGGCTTGCCTGCCGGATTGACCG
CTGATCCGGATGCCTATGACGCCTGGTTCAGGGCGAAGGTACAGGAAGCGCTGGACGATCCAAGGCCCACAACGCCCCAT
GCCAAGGCGATGCAAGACGCCCAGGCATTGATTGACGGGAAGCGCCTTGCCAAATCTTGA

Structures

Antitoxin

• AlphaFold DB: A0A1N7QLX2