Detailed information of TA system TA052850

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 13698..14259
• Replicon: plasmid pP54_b
• Accession: NZ_CP010652
• Organism: Phaeobacter inhibens strain P54

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A917AH87
• Locus tag: PhaeoP54_RS18830
• Protein ID: WP_071974127.1
• Coordinates: 13984..14259 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1N7QLX2
• Locus tag: PhaeoP54_RS18825
• Protein ID: WP_044353023.1
• Coordinates: 13698..13997 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PhaeoP54_RS18800	9370..9672	+	303	Protein_8	antirestriction protein	-
PhaeoP54_RS18805	9743..10132	+	390	WP_090525076.1	DUF3768 domain-containing protein	-
PhaeoP54_RS18810	10288..12270	+	1983	WP_090525078.1	ParB/RepB/Spo0J family partition protein	-
PhaeoP54_RS18815	12344..12937	+	594	WP_090525080.1	regulator	-
PhaeoP54_RS18820	12937..13593	+	657	WP_090525082.1	hypothetical protein	-
PhaeoP54_RS18825	13698..13997	+	300	WP_044353023.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
PhaeoP54_RS18830	13984..14259	+	276	WP_071974127.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
PhaeoP54_RS18835	14367..18629	+	4263	WP_102877816.1	strawberry notch family protein	-
PhaeoP54_RS18840	18751..19137	+	387	WP_090525086.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..84290	84290

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-54)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10388.92 Da
• Isoelectric Point: 4.5837

>T52850 WP_071974127.1 NZ_CP010652:13984-14259 [Phaeobacter inhibens]
MPNLEWKATAIADLLAIIDYISDDNPDAAQVLKDEIEHKTSLLPERPQMYRAGRVDGTREMVVRPNYIVVYAESPEMVTI
LRVLHAAQQWP

Nucleotide

• Length: 276 bp

>T52850 NZ_CP010652:13984-14259 [Phaeobacter inhibens]
TTGCCAAATCTTGAATGGAAAGCCACGGCCATAGCCGACTTGCTGGCAATCATTGACTACATCTCTGACGACAACCCGGA
TGCCGCCCAAGTTCTCAAAGACGAGATTGAACACAAGACGTCCCTCCTTCCAGAACGCCCTCAGATGTACCGCGCGGGCC
GTGTGGACGGGACTAGGGAGATGGTTGTTCGGCCGAACTACATCGTGGTTTATGCTGAAAGCCCTGAGATGGTGACCATT
TTGCGCGTTCTTCATGCTGCGCAGCAGTGGCCATGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10462.91 Da
• Isoelectric Point: 5.6448

>AT52850 WP_044353023.1 NZ_CP010652:13698-13997 [Phaeobacter inhibens]
MPAQTSMLHVRVDDQLKAQASDALAGVGLTLSDAVRILLTRVAAEGGLPAGLTADPDAYDAWFRAKVQEALDDPRPTTPH
AKAMQDAQALIDGKRLAKS

Nucleotide

• Length: 300 bp

>AT52850 NZ_CP010652:13698-13997 [Phaeobacter inhibens]
ATGCCTGCCCAAACATCCATGCTTCATGTCCGTGTTGACGATCAGCTGAAAGCACAGGCTTCGGACGCACTTGCGGGCGT
CGGTCTGACGCTCTCCGACGCGGTGCGTATTCTTCTGACCCGCGTGGCCGCAGAAGGCGGCTTGCCTGCCGGATTGACCG
CTGATCCGGATGCCTATGACGCCTGGTTCAGGGCGAAGGTACAGGAAGCGCTGGACGATCCAAGGCCCACAACGCCCCAT
GCCAAGGCGATGCAAGACGCCCAGGCATTGATTGACGGGAAGCGCCTTGCCAAATCTTGA

Structures

Antitoxin

• AlphaFold DB: A0A1N7QLX2