Detailed information of TA system TA052844

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1076937..1078491
• Replicon: chromosome
• Accession: NZ_CP010588
• Organism: Phaeobacter gallaeciensis strain P11

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: V9WF80
• Locus tag: PhaeoP11_RS05170
• Protein ID: WP_024096523.1
• Coordinates: 1077190..1078491 (+)
• Length: 434 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: PhaeoP11_RS05165
• Protein ID: WP_024096522.1
• Coordinates: 1076937..1077188 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PhaeoP11_RS05155	1074586..1075368	+	783	WP_024096519.1	hypothetical protein	-
PhaeoP11_RS05160	1075933..1076796	+	864	WP_096596711.1	hypothetical protein	-
PhaeoP11_RS05165	1076937..1077188	+	252	WP_024096522.1	helix-turn-helix domain-containing protein	Antitoxin
PhaeoP11_RS05170	1077190..1078491	+	1302	WP_024096523.1	type II toxin-antitoxin system HipA family toxin	Toxin
PhaeoP11_RS05175	1078762..1078959	+	198	WP_024096524.1	hypothetical protein	-
PhaeoP11_RS05180	1079227..1080129	-	903	WP_024096525.1	LysR family transcriptional regulator	-
PhaeoP11_RS05185	1080226..1080831	+	606	WP_024096526.1	putative protein-disulfide isomerase	-
PhaeoP11_RS05190	1080849..1081712	+	864	WP_024096527.1	MBL fold metallo-hydrolase	-
PhaeoP11_RS05195	1081821..1082363	+	543	WP_199535422.1	nuclear transport factor 2 family protein	-
PhaeoP11_RS05200	1082445..1082846	+	402	Protein_1008	DoxX family protein	-
PhaeoP11_RS05205	1083006..1083485	+	480	WP_199535421.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	katA	1075635..1177396	101761

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (10-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-67)

Sequences

Toxin

Protein

• Length: 434 a.a.
• Molecular weight: 48048.86 Da
• Isoelectric Point: 5.5137

>T52844 WP_024096523.1 NZ_CP010588:1077190-1078491 [Phaeobacter gallaeciensis]
MGRKRSYTPLNVFLNSRLVGQLVREPSGGVSFAYTRDWLEWEHRMPVSLSLPLQENRYIGAPVMAVFDNLLPDSDLIRRK
VAERVGAEGVDAFSLLSQIGRDCIGALQFLPDGQEPQPMSELTGEGVNEAQIGAILSDLDLAPLGIRRENDFRISVAGAQ
EKTALLRKDGQWIEPTGTTPTTHIIKPQIGRLPNGMDLSDSVENEYLCLKLMEAFGLRVANAEMAQFGEKKALVVERFDR
RWTSVGRLIRLPQEDCCQALSVVPTQKYQNEGGPGISDIMDLLLGSDDPNKDRYDFFKANVLFWLLGATDGHGKNFSVSL
LPGGRFRMTPLYDVLTVQPTVDARQIERKYFKLAMNFGNSNHYKVSNIVGRHIVETGVQSGLSRAVVQGLFEELQETSHA
IVEATFNQLPADLPESLLASIDGALKARLHLLN

Nucleotide

• Length: 1302 bp

>T52844 NZ_CP010588:1077190-1078491 [Phaeobacter gallaeciensis]
ATGGGCCGCAAGCGCAGCTACACACCGCTGAACGTTTTCCTGAACTCGCGGCTCGTGGGCCAATTGGTACGTGAGCCCTC
GGGCGGCGTCAGTTTCGCCTATACGCGAGACTGGCTCGAATGGGAGCACCGGATGCCTGTGTCGCTATCATTGCCATTGC
AGGAAAACCGCTACATCGGCGCACCTGTGATGGCCGTCTTTGACAACCTGTTGCCCGACAGTGACCTCATTCGACGAAAA
GTCGCAGAGCGCGTCGGGGCCGAGGGCGTCGATGCCTTTAGCTTGCTGTCCCAAATTGGGCGCGACTGCATTGGTGCGCT
GCAGTTCCTTCCCGACGGGCAAGAGCCACAGCCAATGTCCGAGCTGACTGGAGAAGGTGTGAATGAAGCTCAGATTGGGG
CAATTCTGAGCGACCTCGATCTCGCGCCACTGGGTATTCGCCGCGAAAATGACTTTCGCATTTCTGTCGCGGGCGCGCAG
GAAAAAACAGCGCTGCTTCGTAAAGATGGCCAGTGGATTGAGCCAACCGGTACGACGCCAACCACGCACATCATCAAGCC
GCAAATCGGCAGGCTGCCCAATGGCATGGATCTGTCTGACAGTGTAGAAAACGAATACCTTTGCCTCAAGTTGATGGAGG
CGTTTGGGCTTCGGGTTGCGAATGCCGAGATGGCGCAATTCGGCGAAAAGAAAGCCTTGGTCGTTGAGCGTTTTGATCGG
CGCTGGACGTCAGTTGGCCGCTTGATCCGTCTGCCGCAGGAGGATTGCTGTCAAGCATTGTCCGTTGTGCCTACCCAGAA
GTACCAGAACGAGGGCGGCCCAGGAATCTCAGATATTATGGATCTATTGTTGGGAAGTGATGACCCCAACAAAGACCGGT
ACGATTTTTTCAAAGCGAATGTCCTGTTCTGGTTGCTGGGCGCGACAGACGGACATGGTAAAAACTTCAGCGTCAGCCTC
TTACCCGGCGGTCGCTTTCGCATGACACCGCTTTACGACGTTTTGACGGTGCAGCCGACTGTCGATGCGCGACAGATCGA
GCGAAAGTACTTCAAACTGGCCATGAATTTCGGCAACTCAAACCACTACAAGGTTTCGAATATCGTTGGTCGGCACATCG
TGGAGACTGGAGTTCAATCCGGCTTATCCCGCGCTGTCGTACAGGGCCTATTCGAAGAACTGCAGGAGACCTCGCACGCG
ATCGTTGAGGCCACGTTCAACCAGCTTCCAGCGGATCTCCCAGAGTCGTTGCTTGCTTCGATCGATGGCGCGCTGAAGGC
CAGGTTGCACCTGTTGAACTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9128.43 Da
• Isoelectric Point: 8.7279

>AT52844 WP_024096522.1 NZ_CP010588:1076937-1077188 [Phaeobacter gallaeciensis]
MKHLVRTSKNLGHAIRQARKAKNLTQKELASMSGVWQETISKIENGSGGTKLETVFDLIAALELEITVTERSKGTSDGLE
DIF

Nucleotide

• Length: 252 bp

>AT52844 NZ_CP010588:1076937-1077188 [Phaeobacter gallaeciensis]
ATGAAGCACCTCGTTCGTACATCAAAAAACTTGGGCCACGCAATTCGCCAGGCTCGGAAAGCAAAGAACCTTACCCAGAA
GGAACTCGCCTCGATGAGCGGTGTCTGGCAGGAGACAATTTCCAAGATCGAGAACGGCAGTGGGGGAACCAAGCTGGAAA
CGGTATTCGATTTGATCGCGGCCCTGGAGCTCGAAATTACGGTGACCGAGCGCAGCAAGGGCACATCAGACGGGCTTGAG
GACATTTTCTGA

Structures

Toxin

• AlphaFold DB: V9WF80