Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /SpoIISA(toxin) |
| Location | 2424681..2425659 | Replicon | chromosome |
| Accession | NZ_CP010577 | ||
| Organism | Bacillus thuringiensis serovar morrisoni strain BGSC 4AA1 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | B7IX38 |
| Locus tag | SD98_RS12730 | Protein ID | WP_000624981.1 |
| Coordinates | 2424681..2425418 (+) | Length | 246 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | B7IX39 |
| Locus tag | SD98_RS12735 | Protein ID | WP_000237817.1 |
| Coordinates | 2425531..2425659 (+) | Length | 43 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SD98_RS12710 | 2420326..2421108 | + | 783 | WP_016077713.1 | class I SAM-dependent methyltransferase | - |
| SD98_RS12715 | 2421266..2422942 | - | 1677 | Protein_2431 | alpha-keto acid decarboxylase family protein | - |
| SD98_RS12720 | 2423057..2423539 | + | 483 | WP_000191905.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
| SD98_RS12725 | 2423705..2424442 | + | 738 | WP_000594159.1 | 2,3-diphosphoglycerate-dependent phosphoglycerate mutase | - |
| SD98_RS12730 | 2424681..2425418 | + | 738 | WP_000624981.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| SD98_RS12735 | 2425531..2425659 | + | 129 | WP_000237817.1 | hypothetical protein | Antitoxin |
| SD98_RS12740 | 2425732..2425908 | + | 177 | WP_000852629.1 | stage II sporulation protein SB | - |
| SD98_RS12745 | 2425927..2426316 | - | 390 | WP_000712655.1 | YxeA family protein | - |
| SD98_RS12750 | 2426528..2427997 | + | 1470 | WP_000287540.1 | beta-Ala-His dipeptidase | - |
| SD98_RS12755 | 2428310..2429119 | + | 810 | WP_016077711.1 | C39 family peptidase | - |
| SD98_RS12760 | 2429145..2429750 | + | 606 | WP_000517276.1 | hypothetical protein | - |
| SD98_RS12765 | 2429891..2430142 | - | 252 | WP_000821942.1 | response regulator transcription factor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 246 a.a. Molecular weight: 28335.09 Da Isoelectric Point: 8.2998
>T52816 WP_000624981.1 NZ_CP010577:2424681-2425418 [Bacillus thuringiensis serovar morrisoni]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNVFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNVFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
Download Length: 738 bp
>T52816 NZ_CP010577:2424681-2425418 [Bacillus thuringiensis serovar morrisoni]
ATGATCTCTAACATTCGAATTGGCTTATTTGTTTTAGCGATTGTCTTTGTAGTCCTTGTTTTCTTTTATTGGAAAAATGA
GGAGTTGTACGAGGAGAAAAAGCAACGTATTAGAAAGACTTGGTATGGTTTGTTTATCATATCTGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCAATGGTTATTTTTGTTGATATTGCGTTC
ATTTTAACGCCTAATATTTCAGAAATATGGGGTGCGAAATTTAGCGATATTGGCAAGACAGTTCAATCAATAAAACGATC
ATTAATTGCATCTAAAGCGAGAGGAGAAATATACACCACAATTATTCAAAATGTTAATCCAGCAGTATTCGGTACGATGG
AATGGCATACGGAAGAAGAATATACAAAGAGCTTAAATGTATTTTTAGATTCATATGGGGAAAAAATTGGCGCGAAAATT
GTTGTTTTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATTCGCTCGCAATTTAGTATTATCGTTCCGTTAGA
ACATATCGAGCAATTGAATGAGCAGAAAGCAGTGCAAGTAGAAAATGTCGGGATCATACCAGCAAAAATAGTAAGTGATG
TTTTCATTGTTATTGATGGAAAGAAAAATAACCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA
ATGATCTCTAACATTCGAATTGGCTTATTTGTTTTAGCGATTGTCTTTGTAGTCCTTGTTTTCTTTTATTGGAAAAATGA
GGAGTTGTACGAGGAGAAAAAGCAACGTATTAGAAAGACTTGGTATGGTTTGTTTATCATATCTGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCAATGGTTATTTTTGTTGATATTGCGTTC
ATTTTAACGCCTAATATTTCAGAAATATGGGGTGCGAAATTTAGCGATATTGGCAAGACAGTTCAATCAATAAAACGATC
ATTAATTGCATCTAAAGCGAGAGGAGAAATATACACCACAATTATTCAAAATGTTAATCCAGCAGTATTCGGTACGATGG
AATGGCATACGGAAGAAGAATATACAAAGAGCTTAAATGTATTTTTAGATTCATATGGGGAAAAAATTGGCGCGAAAATT
GTTGTTTTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATTCGCTCGCAATTTAGTATTATCGTTCCGTTAGA
ACATATCGAGCAATTGAATGAGCAGAAAGCAGTGCAAGTAGAAAATGTCGGGATCATACCAGCAAAAATAGTAAGTGATG
TTTTCATTGTTATTGATGGAAAGAAAAATAACCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA
Antitoxin
Download Length: 43 a.a. Molecular weight: 4981.37 Da Isoelectric Point: 3.9150
>AT52816 WP_000237817.1 NZ_CP010577:2425531-2425659 [Bacillus thuringiensis serovar morrisoni]
VVKDYDNDFFKEDNEDTTDFSLIKGDALQQVEELEEELKRKS
VVKDYDNDFFKEDNEDTTDFSLIKGDALQQVEELEEELKRKS
Download Length: 129 bp
>AT52816 NZ_CP010577:2425531-2425659 [Bacillus thuringiensis serovar morrisoni]
GTGGTAAAAGATTATGACAATGATTTTTTTAAAGAAGATAACGAAGATACAACAGATTTCTCTTTAATAAAAGGGGATGC
GTTGCAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATCATAA
GTGGTAAAAGATTATGACAATGATTTTTTTAAAGAAGATAACGAAGATACAACAGATTTCTCTTTAATAAAAGGGGATGC
GTTGCAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6D1SWF1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | B7IX39 |