Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 222041..222683 Replicon chromosome
Accession NZ_CP010577
Organism Bacillus thuringiensis serovar morrisoni strain BGSC 4AA1

Toxin (Protein)


Gene name pemK Uniprot ID R8I8B8
Locus tag SD98_RS01255 Protein ID WP_000635965.1
Coordinates 222333..222683 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag SD98_RS01250 Protein ID WP_000004570.1
Coordinates 222041..222328 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SD98_RS01225 217358..218320 + 963 WP_016078970.1 UV DNA damage repair endonuclease UvsE -
SD98_RS01230 218313..218885 - 573 WP_016078971.1 rhomboid family intramembrane serine protease -
SD98_RS01235 218979..219338 + 360 WP_000583417.1 holo-ACP synthase -
SD98_RS01240 219495..220445 + 951 WP_003306148.1 outer membrane lipoprotein carrier protein LolA -
SD98_RS01245 220563..221732 + 1170 WP_000390595.1 alanine racemase -
SD98_RS01250 222041..222328 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
SD98_RS01255 222333..222683 + 351 WP_000635965.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
SD98_RS01260 222751..224919 + 2169 WP_016078972.1 RNA-binding transcriptional accessory protein -
SD98_RS31875 224977..225093 - 117 WP_001143640.1 cortex morphogenetic protein CmpA -
SD98_RS01270 225289..225747 + 459 WP_000343553.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12948.04 Da        Isoelectric Point: 5.7168

>T52815 WP_000635965.1 NZ_CP010577:222333-222683 [Bacillus thuringiensis serovar morrisoni]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMSRVDEALQISLGLIDF

Download         Length: 351 bp

>T52815 NZ_CP010577:222333-222683 [Bacillus thuringiensis serovar morrisoni]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTATGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAACGCTTAACGGACAAAATCACTCATTTAGATGAAGTGATGATGAGTCGTGTAGATGAAGCGTT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT52815 WP_000004570.1 NZ_CP010577:222041-222328 [Bacillus thuringiensis serovar morrisoni]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT52815 NZ_CP010577:222041-222328 [Bacillus thuringiensis serovar morrisoni]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAATTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTATATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCG
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A366G118

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References