Detailed information of TA system TA052809

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 3893415..3893920
• Replicon: chromosome
• Accession: NZ_CP010555
• Organism: Pseudomonas aeruginosa strain FRD1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: EG09_RS17730
• Protein ID: WP_003083773.1
• Coordinates: 3893415..3893696 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: EG09_RS17735
• Protein ID: WP_003083775.1
• Coordinates: 3893693..3893920 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EG09_RS17705	3888667..3890016	+	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-
EG09_RS17710	3890065..3890751	+	687	WP_003083762.1	FadR family transcriptional regulator	-
EG09_RS17715	3890852..3891585	+	734	Protein_3551	GntR family transcriptional regulator	-
EG09_RS17720	3891789..3892175	+	387	WP_014602345.1	aegerolysin family protein	-
EG09_RS17725	3892207..3893115	-	909	WP_003083769.1	LysR family transcriptional regulator	-
EG09_RS17730	3893415..3893696	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
EG09_RS17735	3893693..3893920	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
EG09_RS17740	3894096..3894716	-	621	WP_003101226.1	hypothetical protein	-
EG09_RS17745	3894817..3895317	+	501	WP_003101228.1	LEA type 2 family protein	-
EG09_RS17750	3895390..3895731	+	342	WP_003101229.1	alkylphosphonate utilization protein	-
EG09_RS17755	3895813..3897240	-	1428	WP_003083784.1	GABA permease	-
EG09_RS17760	3897409..3898902	-	1494	WP_003083788.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T52809 WP_003083773.1 NZ_CP010555:c3893696-3893415 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T52809 NZ_CP010555:c3893696-3893415 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT52809 WP_003083775.1 NZ_CP010555:c3893920-3893693 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT52809 NZ_CP010555:c3893920-3893693 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9