Detailed information of TA system TA052803

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 2684881..2685542
• Replicon: chromosome
• Accession: NZ_CP010554
• Organism: Rugosibacter aromaticivorans strain Ca6

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: PG1C_RS13285
• Protein ID: WP_202635212.1
• Coordinates: 2684881..2685294 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: PG1C_RS13290
• Protein ID: WP_202635213.1
• Coordinates: 2685291..2685542 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PG1C_RS13270	2682110..2683336	+	1227	WP_202635209.1	porin	-
PG1C_RS13275	2683405..2683995	-	591	WP_202635210.1	esterase	-
PG1C_RS13280	2684017..2684844	-	828	WP_202635211.1	undecaprenyl-diphosphate phosphatase	-
PG1C_RS13285	2684881..2685294	-	414	WP_202635212.1	type II toxin-antitoxin system VapC family toxin	Toxin
PG1C_RS13290	2685291..2685542	-	252	WP_202635213.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
PG1C_RS13295	2685952..2687820	-	1869	WP_202635214.1	phosphomethylpyrimidine synthase ThiC	-
PG1C_RS13300	2688273..2688938	+	666	WP_202637076.1	TetR/AcrR family transcriptional regulator	-
PG1C_RS13305	2689014..2690063	+	1050	WP_202635215.1	efflux RND transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-120)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-62)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15157.46 Da
• Isoelectric Point: 6.4735

>T52803 WP_202635212.1 NZ_CP010554:c2685294-2684881 [Rugosibacter aromaticivorans]
MSYLLDTNVLSELRRKTPNAGVVEWFARRPASTLFLSVLTLGELRKGVEGMADADRRTALLDWLEAELPIFFTGRILSVD
VQVADRWGRLMAAAKRPVPAIDSLLAATAAHHGLSLVTRNVRDFVDSGLDVINPWTD

Nucleotide

• Length: 414 bp

>T52803 NZ_CP010554:c2685294-2684881 [Rugosibacter aromaticivorans]
TTGAGCTATCTGCTCGATACCAATGTTCTCTCGGAACTGCGCCGCAAAACGCCCAACGCTGGTGTTGTCGAGTGGTTTGC
CCGGCGTCCGGCATCCACCTTGTTCCTGAGTGTGTTGACGCTGGGCGAATTGCGCAAGGGTGTCGAAGGCATGGCTGACG
CAGATCGCCGGACCGCCCTGCTGGATTGGCTCGAAGCGGAACTGCCGATCTTCTTTACCGGCCGGATTCTCTCAGTCGAT
GTGCAGGTGGCTGACCGCTGGGGGCGGTTGATGGCGGCAGCGAAGCGCCCGGTTCCGGCTATCGACAGCCTATTGGCAGC
GACCGCCGCGCATCATGGCCTGAGCCTGGTCACTCGCAACGTGCGCGATTTTGTTGATTCAGGATTGGATGTCATCAACC
CGTGGACCGATTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9356.58 Da
• Isoelectric Point: 5.1114

>AT52803 WP_202635213.1 NZ_CP010554:c2685542-2685291 [Rugosibacter aromaticivorans]
MHTWQMQEAKARLSEVVKLAESEGPQDITLHGRSVAVVLSRATFEHLSGSGQSLVEFMRQSPLYGLEEIEFERDRSAARE
VVL

Nucleotide

• Length: 252 bp

>AT52803 NZ_CP010554:c2685542-2685291 [Rugosibacter aromaticivorans]
ATGCACACATGGCAAATGCAAGAAGCGAAAGCGCGCCTGTCTGAAGTCGTAAAACTCGCTGAAAGCGAGGGGCCGCAAGA
CATCACGCTGCACGGCCGGTCAGTGGCTGTGGTGCTGTCACGGGCAACCTTTGAGCACCTCTCAGGCAGCGGACAATCAC
TCGTGGAGTTCATGCGCCAATCGCCGTTGTATGGGCTCGAAGAAATCGAGTTCGAACGCGACCGCAGCGCCGCGCGTGAG
GTCGTGCTTTGA