Detailed information of TA system TA052802

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relE/YoeB-YefM
• Location: 2335681..2336183
• Replicon: chromosome
• Accession: NZ_CP010554
• Organism: Rugosibacter aromaticivorans strain Ca6

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: PG1C_RS11625
• Protein ID: WP_202634923.1
• Coordinates: 2335681..2335935 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: PG1C_RS11630
• Protein ID: WP_202634924.1
• Coordinates: 2335932..2336183 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PG1C_RS11585	2331613..2331957	-	345	WP_202634916.1	hypothetical protein	-
PG1C_RS11590	2332048..2332461	+	414	WP_202634917.1	hypothetical protein	-
PG1C_RS11595	2332484..2333143	+	660	WP_202634918.1	hypothetical protein	-
PG1C_RS11600	2333342..2333623	+	282	WP_202634919.1	type II toxin-antitoxin system RelE/ParE family toxin	-
PG1C_RS11605	2333637..2333963	+	327	WP_202634920.1	HigA family addiction module antidote protein	-
PG1C_RS11610	2334072..2334305	+	234	WP_202634921.1	hypothetical protein	-
PG1C_RS11615	2334287..2334484	+	198	WP_202637050.1	type II toxin-antitoxin system HicA family toxin	-
PG1C_RS11620	2334803..2335486	+	684	WP_202634922.1	type 1 glutamine amidotransferase domain-containing protein	-
PG1C_RS11625	2335681..2335935	-	255	WP_202634923.1	Txe/YoeB family addiction module toxin	Toxin
PG1C_RS11630	2335932..2336183	-	252	WP_202634924.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
PG1C_RS11635	2336539..2336796	+	258	WP_202634925.1	BrnT family toxin	-
PG1C_RS11640	2336800..2337075	+	276	WP_202634926.1	hypothetical protein	-
PG1C_RS11645	2337206..2337505	+	300	WP_202634927.1	GIY-YIG nuclease family protein	-
PG1C_RS11650	2338096..2340488	+	2393	Protein_2289	5-histidylcysteine sulfoxide synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10323.90 Da
• Isoelectric Point: 9.8319

>T52802 WP_202634923.1 NZ_CP010554:c2335935-2335681 [Rugosibacter aromaticivorans]
MKLVFADEAWEDYLYWQKRDKRMVERINKLIRETQREPFTGVGKPEPLKHALSGFWSRRITDEHRMVYRVEDNALLIAQL
RFHY

Nucleotide

• Length: 255 bp

>T52802 NZ_CP010554:c2335935-2335681 [Rugosibacter aromaticivorans]
ATGAAGCTGGTCTTTGCAGATGAGGCATGGGAAGACTACCTCTATTGGCAAAAGCGAGACAAACGTATGGTTGAACGGAT
TAACAAGTTGATACGCGAGACGCAACGCGAGCCCTTCACCGGAGTTGGAAAGCCTGAACCTTTAAAGCACGCGCTATCAG
GGTTCTGGTCACGTCGCATAACAGACGAGCATCGCATGGTATATCGCGTCGAAGACAATGCACTGTTGATTGCCCAATTG
CGCTTTCATTACTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9075.54 Da
• Isoelectric Point: 8.9767

>AT52802 WP_202634924.1 NZ_CP010554:c2336183-2335932 [Rugosibacter aromaticivorans]
MDAITYTTIRANLASAMDRVCNDHEALIITRNGEQAVVMLSLEDYKALEETAYLLRTPANAKRLLTAVGQLNAGKGVARK
LVK

Nucleotide

• Length: 252 bp

>AT52802 NZ_CP010554:c2336183-2335932 [Rugosibacter aromaticivorans]
ATGGATGCAATTACCTACACTACTATCCGCGCAAACCTCGCTAGCGCTATGGATCGGGTTTGCAACGATCACGAAGCTTT
AATTATCACCCGCAACGGAGAACAGGCGGTGGTGATGCTCTCGCTCGAAGACTACAAGGCGCTTGAAGAAACCGCCTACC
TCTTGCGCACACCCGCCAACGCCAAGCGCCTCTTGACGGCGGTCGGACAACTAAACGCCGGCAAAGGCGTTGCGCGGAAA
TTGGTTAAATGA