Detailed information of TA system TA052795

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 454966..455510
• Replicon: chromosome
• Accession: NZ_CP010552
• Organism: Candidatus Thioglobus autotrophicus strain EF1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: SP60_RS08225
• Protein ID: WP_082319675.1
• Coordinates: 455211..455510 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0M5LKR3
• Locus tag: SP60_RS02405
• Protein ID: WP_053951121.1
• Coordinates: 454966..455223 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SP60_RS02385	450396..451937	-	1542	WP_082319625.1	N-acetylneuraminate synthase family protein	-
SP60_RS02390	451961..453064	-	1104	WP_053951118.1	Gfo/Idh/MocA family oxidoreductase	-
SP60_RS02395	453381..453914	+	534	WP_053951119.1	D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase	-
SP60_RS02400	453919..454923	+	1005	WP_053951120.1	ADP-glyceromanno-heptose 6-epimerase	-
SP60_RS02405	454966..455223	+	258	WP_053951121.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SP60_RS08225	455211..455510	+	300	WP_082319675.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SP60_RS02410	455512..456939	+	1428	WP_053952196.1	D-glycero-beta-D-manno-heptose-7-phosphate kinase	-
SP60_RS02415	456941..457510	+	570	WP_053951122.1	D-sedoheptulose 7-phosphate isomerase	-
SP60_RS02420	457521..458453	-	933	WP_053951123.1	lipopolysaccharide heptosyltransferase II	-
SP60_RS02425	458453..459313	-	861	WP_053951124.1	glycosyl transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-60)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11490.56 Da
• Isoelectric Point: 9.6104

>T52795 WP_082319675.1 NZ_CP010552:455211-455510 [Candidatus Thioglobus autotrophicus]
MAKVIWTESALSELNFIVQYISLDKPSAANKLIKKILSATKQLELFPELGRTPSEISHLNYLEIIVNPCRIFYRIDDNKV
YIVYIMRGKQDLKKYLLNG

Nucleotide

• Length: 300 bp

>T52795 NZ_CP010552:455211-455510 [Candidatus Thioglobus autotrophicus]
ATGGCTAAAGTAATTTGGACTGAATCCGCCCTATCAGAACTCAATTTTATTGTTCAATATATTTCCCTAGATAAGCCTAG
TGCCGCAAATAAATTAATTAAAAAAATTCTAAGCGCAACCAAACAGCTCGAATTATTTCCAGAATTAGGGCGAACGCCAT
CAGAAATTAGCCATCTAAATTATTTGGAAATCATTGTCAATCCTTGTCGAATCTTTTATCGAATAGATGATAATAAAGTC
TATATTGTTTATATAATGAGAGGCAAACAAGATTTAAAAAAATACCTTCTAAATGGTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9881.42 Da
• Isoelectric Point: 4.9314

>AT52795 WP_053951121.1 NZ_CP010552:454966-455223 [Candidatus Thioglobus autotrophicus]
MKIELVTTLKRQATKILSDLHASKEPVLITEHGVPSAYLIDVDDYELTKRRIEILEGIARGETAILERQLYSQEEVEEKM
EKWLK

Nucleotide

• Length: 258 bp

>AT52795 NZ_CP010552:454966-455223 [Candidatus Thioglobus autotrophicus]
ATGAAAATAGAATTAGTTACCACACTTAAACGACAGGCAACCAAGATACTCTCTGATCTGCATGCTTCTAAAGAGCCTGT
ACTGATCACTGAGCACGGGGTTCCTTCAGCTTATTTAATTGATGTTGATGATTATGAGCTAACAAAAAGGCGCATAGAAA
TTCTTGAAGGTATTGCTCGTGGCGAAACCGCAATTCTTGAAAGGCAACTGTACTCACAAGAAGAGGTTGAAGAAAAAATG
GAAAAATGGCTAAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0M5LKR3