Detailed information of TA system TA052794

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 128959..129490
• Replicon: chromosome
• Accession: NZ_CP010552
• Organism: Candidatus Thioglobus autotrophicus strain EF1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: SP60_RS08205
• Protein ID: WP_082319672.1
• Coordinates: 128959..129246 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A0M4P7T7
• Locus tag: SP60_RS00685
• Protein ID: WP_053950811.1
• Coordinates: 129260..129490 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SP60_RS00675	125200..126375	+	1176	WP_053950809.1	pyridoxal phosphate-dependent aminotransferase	-
SP60_RS00680	126372..128540	-	2169	WP_053950810.1	YgiQ family radical SAM protein	-
SP60_RS08205	128959..129246	-	288	WP_082319672.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SP60_RS00685	129260..129490	-	231	WP_053950811.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
SP60_RS00690	129919..130428	+	510	WP_053950812.1	heme-binding protein	-
SP60_RS00695	130708..130995	-	288	WP_053950813.1	type II toxin-antitoxin system RelE/ParE family toxin	-
SP60_RS00700	130988..131233	-	246	WP_053950814.1	type II toxin-antitoxin system ParD family antitoxin	-
SP60_RS00705	131550..132596	+	1047	WP_053950815.1	Fic family protein	-
SP60_RS00710	132598..132804	-	207	WP_053950816.1	hypothetical protein	-
SP60_RS00720	133560..134150	-	591	WP_053950817.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Antitoxin ParD (3-70)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10795.12 Da
• Isoelectric Point: 4.7103

>T52794 WP_082319672.1 NZ_CP010552:c129246-128959 [Candidatus Thioglobus autotrophicus]
ISYSLTAEAEEDIISIFIEGGKGFGVNQAQAYHLSLSNTFELLSQNPELAQQRFEINPPVRIYPFQSHLIVYLVDSSNNI
LVVRVRHQKEGWFDG

Nucleotide

• Length: 288 bp

>T52794 NZ_CP010552:c129246-128959 [Candidatus Thioglobus autotrophicus]
ATCAGTTATTCTCTAACTGCTGAGGCCGAAGAAGATATTATTTCAATTTTTATTGAAGGTGGCAAAGGATTCGGTGTTAA
CCAAGCGCAAGCATATCACTTATCTTTATCAAATACATTTGAACTACTAAGTCAAAATCCTGAGCTGGCTCAGCAAAGAT
TTGAGATTAACCCACCTGTAAGAATTTATCCTTTTCAATCCCATTTAATTGTCTATCTTGTTGATAGTAGTAATAATATA
TTAGTGGTTAGAGTTAGGCATCAAAAAGAAGGTTGGTTTGATGGCTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8586.81 Da
• Isoelectric Point: 8.5320

>AT52794 WP_053950811.1 NZ_CP010552:c129490-129260 [Candidatus Thioglobus autotrophicus]
MATMNVSLPNEMKTWVEFQAQNSGRYTNTSDYVRDLIRKDQDTSIKIQQMQAMVTKGLESGVGSRSMEELAKVALK

Nucleotide

• Length: 231 bp

>AT52794 NZ_CP010552:c129490-129260 [Candidatus Thioglobus autotrophicus]
ATGGCTACAATGAATGTTTCATTACCAAATGAAATGAAAACTTGGGTAGAGTTTCAAGCGCAAAACTCTGGTAGATATAC
AAATACCAGCGATTACGTTAGAGATTTAATCAGAAAAGATCAAGATACCAGTATCAAAATTCAGCAAATGCAGGCTATGG
TAACTAAAGGTCTTGAGAGTGGTGTAGGGTCACGATCTATGGAAGAGTTAGCTAAAGTAGCTCTTAAATAA

Structures

Antitoxin

• AlphaFold DB: A0A0M4P7T7