Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1644273..1644807 Replicon chromosome
Accession NZ_CP010537
Organism Cupriavidus basilensis strain 4G11

Toxin (Protein)


Gene name relE Uniprot ID A0A0C4YR90
Locus tag RR42_RS27995 Protein ID WP_043354772.1
Coordinates 1644517..1644807 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0C4YKK6
Locus tag RR42_RS27990 Protein ID WP_043354770.1
Coordinates 1644273..1644527 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RR42_RS27970 1640289..1641206 + 918 WP_043354762.1 LysR family transcriptional regulator -
RR42_RS27975 1641524..1642756 + 1233 WP_043354764.1 alpha/beta fold hydrolase -
RR42_RS27980 1642822..1643223 - 402 WP_043354766.1 OsmC family protein -
RR42_RS27985 1643426..1644076 + 651 WP_043354768.1 VTT domain-containing protein -
RR42_RS27990 1644273..1644527 + 255 WP_043354770.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
RR42_RS27995 1644517..1644807 + 291 WP_043354772.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RR42_RS28000 1644831..1645142 - 312 WP_144409983.1 hypothetical protein -
RR42_RS28005 1645206..1646045 + 840 WP_043354773.1 phosphonate ABC transporter ATP-binding protein -
RR42_RS28010 1646115..1647107 + 993 WP_043354775.1 phosphonate ABC transporter substrate-binding protein -
RR42_RS28015 1647216..1648007 + 792 WP_043354777.1 phosphonate ABC transporter, permease protein PhnE -
RR42_RS28020 1648067..1648603 + 537 WP_043354779.1 HD domain-containing protein -
RR42_RS28025 1648647..1649144 + 498 WP_052495030.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-73)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11330.09 Da        Isoelectric Point: 10.5745

>T52791 WP_043354772.1 NZ_CP010537:1644517-1644807 [Cupriavidus basilensis]
MSYELAFHEDALKEWKRLDASIKDQFRKQLEKRLAEPRVQSAKLSGKDMKDVYKIKLRDAGYRLVYEVNDRTVTVLVLAV
GRRDKSEAYRRAGVRR

Download         Length: 291 bp

>T52791 NZ_CP010537:1644517-1644807 [Cupriavidus basilensis]
ATGAGTTATGAGCTCGCCTTTCACGAAGACGCTTTGAAGGAATGGAAGAGACTCGATGCGTCGATCAAGGATCAGTTTCG
AAAACAGCTCGAGAAACGTCTGGCCGAACCCCGGGTGCAGTCTGCCAAGCTCAGCGGCAAGGACATGAAAGACGTCTACA
AGATCAAGCTGCGCGATGCCGGGTACCGGCTGGTGTACGAGGTCAACGATCGTACCGTCACTGTGCTAGTGCTCGCTGTT
GGACGACGGGACAAGAGTGAGGCGTATCGCCGGGCCGGTGTGAGGCGATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9216.55 Da        Isoelectric Point: 5.0790

>AT52791 WP_043354770.1 NZ_CP010537:1644273-1644527 [Cupriavidus basilensis]
MTVTRAIYATATVSITDLRRNPGAIIEEAGNEPVAVLNHNRPAAYLVPAQAFEALMDRLEDIELAEIVRQRRGGKSVKVS
LDEL

Download         Length: 255 bp

>AT52791 NZ_CP010537:1644273-1644527 [Cupriavidus basilensis]
ATGACTGTCACACGCGCCATCTACGCTACCGCGACCGTAAGCATCACGGACCTTCGCCGCAACCCCGGTGCCATCATTGA
GGAGGCCGGTAACGAACCCGTGGCAGTCCTCAATCACAATCGCCCGGCCGCATACCTGGTTCCCGCCCAGGCTTTCGAAG
CACTCATGGACAGGCTCGAGGACATCGAGCTTGCAGAAATCGTTCGGCAGCGTCGCGGCGGGAAGTCCGTAAAGGTGTCG
CTGGATGAGTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C4YR90

Antitoxin

Source ID Structure
AlphaFold DB A0A0C4YKK6

References