Detailed information of TA system TA052790

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 398970..399553
• Replicon: chromosome
• Accession: NZ_CP010537
• Organism: Cupriavidus basilensis strain 4G11

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A0C4YJ95
• Locus tag: RR42_RS22560
• Protein ID: WP_043353178.1
• Coordinates: 398970..399152 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: RR42_RS22565
• Protein ID: WP_043357640.1
• Coordinates: 399164..399553 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RR42_RS22545	394936..396534	+	1599	WP_043353173.1	DUF1800 domain-containing protein	-
RR42_RS22550	396563..397921	+	1359	WP_043353175.1	DUF1501 domain-containing protein	-
RR42_RS22555	398034..398621	-	588	WP_043353177.1	gamma carbonic anhydrase family protein	-
RR42_RS22560	398970..399152	+	183	WP_043353178.1	type II toxin-antitoxin system HicA family toxin	Toxin
RR42_RS22565	399164..399553	+	390	WP_043357640.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
RR42_RS22570	399827..400555	+	729	WP_043353179.1	class I SAM-dependent methyltransferase	-
RR42_RS22575	400816..401649	+	834	WP_082055279.1	hypothetical protein	-
RR42_RS22580	401657..402106	+	450	WP_052494864.1	nuclear transport factor 2 family protein	-
RR42_RS22585	402355..402783	+	429	WP_201777397.1	MarR family transcriptional regulator	-
RR42_RS22590	402969..403394	+	426	WP_043353183.1	organic hydroperoxide resistance protein	-
RR42_RS22595	403539..404465	+	927	WP_043353186.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6633.77 Da
• Isoelectric Point: 11.2470

>T52790 WP_043353178.1 NZ_CP010537:398970-399152 [Cupriavidus basilensis]
MNSADLIKQLRADGWQLVHVVGSHHQFKHSTKLGKVTVPHPKKDLPVGTTRSILKQAGLK

Nucleotide

• Length: 183 bp

>T52790 NZ_CP010537:398970-399152 [Cupriavidus basilensis]
ATGAACAGCGCAGACCTGATCAAACAACTCCGGGCCGATGGCTGGCAACTGGTCCACGTGGTGGGTTCTCACCACCAGTT
CAAGCACTCGACGAAGCTCGGTAAGGTCACGGTGCCGCATCCGAAAAAGGATCTGCCGGTCGGCACCACGCGCAGCATCT
TGAAACAGGCAGGTCTCAAGTAA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 14088.79 Da
• Isoelectric Point: 4.5320

>AT52790 WP_043357640.1 NZ_CP010537:399164-399553 [Cupriavidus basilensis]
MLYPVFVEPGDATHAHGLSFPDFPGCFSAADDWADVPANAQEAVEAHYADGDPVPAPSSPEQWIGNPDYAHGIWMLVDID
LSKVNAKAVRLNISLPERLVQQIDAVAKQRHMSRSAFLAMAAQHEMEHA

Nucleotide

• Length: 390 bp

>AT52790 NZ_CP010537:399164-399553 [Cupriavidus basilensis]
ATGCTCTATCCCGTTTTTGTCGAGCCCGGCGACGCGACCCATGCGCATGGGCTCTCCTTCCCGGACTTCCCTGGCTGCTT
CTCGGCGGCCGACGACTGGGCCGATGTCCCGGCCAATGCGCAGGAAGCCGTGGAGGCTCACTACGCAGATGGCGACCCGG
TTCCGGCTCCTTCGTCTCCCGAGCAGTGGATCGGGAATCCAGACTATGCGCACGGCATCTGGATGCTGGTCGACATTGAT
CTTTCGAAGGTCAACGCTAAAGCGGTGCGGTTGAACATCAGCCTACCCGAGCGCCTGGTGCAACAGATCGACGCCGTAGC
CAAGCAGCGGCACATGTCGCGTTCGGCCTTCCTCGCCATGGCTGCGCAGCATGAGATGGAGCATGCCTGA

Structures

Toxin

• AlphaFold DB: A0A0C4YJ95