52789

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2509200..2510242 Replicon chromosome
Accession NZ_CP010536
Organism Cupriavidus basilensis strain 4G11

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag RR42_RS11725 Protein ID WP_043346896.1
Coordinates 2509200..2509775 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag RR42_RS11730 Protein ID WP_082055013.1
Coordinates 2509772..2510242 (-) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RR42_RS11700 2504927..2505580 - 654 WP_043346888.1 BON domain-containing protein -
RR42_RS11705 2505633..2505932 - 300 WP_082055012.1 universal stress protein -
RR42_RS38580 2506168..2506428 + 261 Protein_2364 alcohol dehydrogenase catalytic domain-containing protein -
RR42_RS39660 2506536..2507070 - 535 Protein_2365 hypothetical protein -
RR42_RS11715 2507214..2507735 - 522 WP_043346893.1 DNA-binding protein -
RR42_RS11720 2508077..2508932 - 856 Protein_2367 tyrosine-type recombinase/integrase -
RR42_RS40430 2508968..2509111 - 144 WP_158408282.1 hypothetical protein -
RR42_RS11725 2509200..2509775 - 576 WP_043346896.1 PIN domain-containing protein Toxin
RR42_RS11730 2509772..2510242 - 471 WP_082055013.1 helix-turn-helix domain-containing protein Antitoxin
RR42_RS11735 2510326..2510964 - 639 Protein_2371 site-specific integrase -
RR42_RS11740 2511035..2512654 - 1620 WP_043346901.1 glutamine-hydrolyzing GMP synthase -
RR42_RS11745 2512629..2513231 - 603 WP_043346905.1 hypothetical protein -
RR42_RS40435 2513230..2513385 + 156 WP_158408283.1 hypothetical protein -
RR42_RS11750 2513373..2514836 - 1464 WP_043346907.1 IMP dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21694.83 Da        Isoelectric Point: 5.2940

>T52789 WP_043346896.1 NZ_CP010536:c2509775-2509200 [Cupriavidus basilensis]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTREQVDRTSDLMDRAIPDGLVEGY
EELVAGLVLPDPDDRHVLAAAIRCGASVIVTFNQRDFPAEMLAPYGIESQHPDEFVDNLLNLDAAAVVSAAQRQRAQLRN
PPIEVDRYLDILLRQGLVQTTKVLATYRSIL

Download         Length: 576 bp

>T52789 NZ_CP010536:c2509775-2509200 [Cupriavidus basilensis]
ATGAGACATTCCCCCTTCACAGCTGTCTACGATGCGTGCGTTCTTTATCCCGCGCCGCTGCGGGACTTCCTCATGTGGCT
GGGCCTGTCAGGAAGATTTCGGGCGCGCTGGAGTCAGGCCATTCATGAGGAATGGAAGCGCAACCTGCTGATCAACCGTC
CCGATCTCACCAGGGAGCAGGTCGACCGGACATCCGATCTAATGGATCGCGCTATTCCTGACGGCCTGGTGGAGGGGTAT
GAGGAACTCGTGGCCGGGCTGGTCTTGCCCGATCCAGACGACCGCCATGTGTTGGCGGCGGCGATTCGCTGCGGGGCAAG
CGTGATCGTGACCTTCAACCAGAGGGATTTCCCGGCAGAGATGCTGGCCCCCTACGGCATCGAATCACAGCATCCCGATG
AGTTCGTGGACAACCTATTGAACCTAGACGCGGCCGCGGTCGTGTCGGCCGCACAGCGCCAGCGAGCCCAACTGAGGAAT
CCGCCGATCGAGGTGGACCGCTACCTCGACATCTTGCTGCGCCAAGGTTTGGTTCAAACCACCAAGGTGCTGGCTACTTA
CCGCTCCATTCTCTGA

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17264.62 Da        Isoelectric Point: 5.5601

>AT52789 WP_082055013.1 NZ_CP010536:c2510242-2509772 [Cupriavidus basilensis]
IMTATAQSKMSLPAEGEVKAAVQGQRALAAYLATQFETQHIQIFDDQKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEAREQASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp

>AT52789 NZ_CP010536:c2510242-2509772 [Cupriavidus basilensis]
ATCATGACCGCCACTGCCCAATCCAAGATGAGCCTGCCCGCGGAGGGAGAGGTGAAGGCGGCCGTGCAGGGTCAGCGTGC
CCTGGCGGCCTACTTGGCCACCCAATTTGAGACGCAGCACATCCAGATCTTCGATGACCAGAAGCAAGCGCACCAAGTGG
AGCTTCCTACCTCGGCGCTGCGCTTGCTGGTGGATATTCTGGCCGAACTGGCCGATGGCAACGCCGTGAAGGTTGTGCCT
GTCCATGCGGAACTGACGACCCAAGAGGCGGCGGATTTGCTCAACGTATCCCGCCCCCATTTTGTCAAACTGCTGGAAGA
TGGGGTGCTAGCGTTTCATCGGACCGGCAAACACCGTAGGGTGAGGTTTGCCGACCTGATGCAGTACAAGGAAGCGCGCG
AGCAAGCCAGCGAGCAAGCGATGGCTGAACTCGCCCAGCAGTCGCAGGAGTTGGGAATGGGGTACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References