Detailed information of TA system TA052788

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2118223..2118890
• Replicon: chromosome
• Accession: NZ_CP010536
• Organism: Cupriavidus basilensis strain 4G11

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0C4Y2L8
• Locus tag: RR42_RS09930
• Protein ID: WP_043346181.1
• Coordinates: 2118474..2118890 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: RR42_RS09925
• Protein ID: WP_043346179.1
• Coordinates: 2118223..2118477 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RR42_RS09905	2113460..2114773	-	1314	WP_043346168.1	fumarylacetoacetase	-
RR42_RS09910	2114781..2115584	-	804	WP_043346171.1	cyclase family protein	-
RR42_RS09915	2115631..2116896	-	1266	WP_043346173.1	MFS transporter	-
RR42_RS09920	2117090..2117797	+	708	WP_052494570.1	TetR/AcrR family transcriptional regulator	-
RR42_RS09925	2118223..2118477	+	255	WP_043346179.1	plasmid stabilization protein	Antitoxin
RR42_RS09930	2118474..2118890	+	417	WP_043346181.1	type II toxin-antitoxin system VapC family toxin	Toxin
RR42_RS09935	2119374..2120453	-	1080	WP_158408278.1	YncE family protein	-
RR42_RS09940	2120903..2121967	-	1065	WP_082054861.1	SMP-30/gluconolactonase/LRE family protein	-
RR42_RS09945	2123168..2123512	-	345	Protein_2002	multidrug transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 14759.95 Da
• Isoelectric Point: 5.1239

>T52788 WP_043346181.1 NZ_CP010536:2118474-2118890 [Cupriavidus basilensis]
MIVLDTNVVSEAMKPESHPAVRAWLDNQAAETLYLSSVTVAELLFGIAALPAGKRKNMLTEAVDGLLALFRDRVLPFDTD
AARHYAELAMLARTSGRGFPTPDGYIAAIAASRGFIVASRDAAPYTAAGVTVINPWEV

Nucleotide

• Length: 417 bp

>T52788 NZ_CP010536:2118474-2118890 [Cupriavidus basilensis]
ATGATCGTCCTGGATACAAACGTCGTTTCCGAGGCGATGAAGCCCGAGTCGCACCCGGCGGTGCGTGCTTGGCTGGACAA
CCAGGCTGCTGAAACGCTGTATCTGTCGAGCGTGACAGTCGCCGAGCTGCTGTTCGGGATCGCGGCACTCCCGGCCGGCA
AGCGAAAGAACATGTTGACGGAGGCCGTTGACGGCCTGTTGGCGCTTTTCCGCGATCGGGTGCTGCCCTTCGACACCGAC
GCAGCACGGCACTATGCCGAGCTGGCCATGCTGGCGAGGACCAGCGGGCGCGGCTTCCCGACGCCTGACGGTTACATTGC
CGCGATCGCGGCTTCGCGCGGGTTCATCGTGGCGTCTCGTGACGCGGCCCCGTACACCGCGGCCGGCGTCACCGTCATCA
ATCCGTGGGAGGTGTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9425.82 Da
• Isoelectric Point: 7.2069

>AT52788 WP_043346179.1 NZ_CP010536:2118223-2118477 [Cupriavidus basilensis]
MAMLTVRNLPDDVHRALRVRAAQHGRSTEAEVREILESVVKPEARIRMGEALAALGRKIGLTGEDFEVFDRVSNKTPAEP
LRFE

Nucleotide

• Length: 255 bp

>AT52788 NZ_CP010536:2118223-2118477 [Cupriavidus basilensis]
ATGGCAATGCTGACCGTTCGTAACCTGCCCGACGACGTGCACCGTGCTCTGCGAGTGCGGGCCGCGCAACATGGTCGCAG
CACCGAGGCCGAAGTCCGCGAGATTCTGGAAAGCGTAGTCAAGCCAGAAGCTCGCATTCGCATGGGCGAAGCCCTTGCGG
CACTCGGCCGCAAGATCGGCCTGACCGGCGAGGATTTCGAGGTCTTCGACCGTGTGAGTAACAAGACGCCGGCCGAGCCG
CTGAGATTTGAATGA

Structures

Toxin

• AlphaFold DB: A0A0C4Y2L8