Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 919021..919498 Replicon chromosome
Accession NZ_CP010526
Organism Staphylococcus aureus subsp. aureus ST772-MRSA-V strain DAR4145

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag RU53_RS04565 Protein ID WP_000052076.1
Coordinates 919021..919209 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag RU53_RS04570 Protein ID WP_001059690.1
Coordinates 919238..919498 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RU53_RS04535 915011..915532 + 522 WP_000824487.1 hypothetical protein -
RU53_RS04540 915873..916559 + 687 WP_001793574.1 thermonuclease family protein -
RU53_RS04545 916916..917116 + 201 WP_001059082.1 cold-shock protein -
RU53_RS04550 917612..917830 - 219 WP_000005886.1 hypothetical protein -
RU53_RS04555 917892..918176 - 285 WP_001004399.1 hypothetical protein -
RU53_RS04560 918264..918833 - 570 WP_001106652.1 hypothetical protein -
RU53_RS04565 919021..919209 - 189 WP_000052076.1 hypothetical protein Toxin
RU53_RS04570 919238..919498 - 261 WP_001059690.1 hypothetical protein Antitoxin
RU53_RS04575 919839..920042 + 204 WP_000145164.1 sterile alpha motif-like domain-containing protein -
RU53_RS04580 920039..920275 - 237 WP_000368687.1 hypothetical protein -
RU53_RS04585 920500..921081 + 582 WP_001140695.1 phosphoglycerate mutase family protein -
RU53_RS04590 921154..921771 - 618 WP_000255557.1 LysE/ArgO family amino acid transporter -
RU53_RS04595 921926..922420 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
RU53_RS04600 922819..923241 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
RU53_RS04605 923389..924105 + 717 WP_000150016.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T52767 WP_000052076.1 NZ_CP010526:c919209-919021 [Staphylococcus aureus subsp. aureus ST772-MRSA-V]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T52767 NZ_CP010526:c919209-919021 [Staphylococcus aureus subsp. aureus ST772-MRSA-V]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT52767 WP_001059690.1 NZ_CP010526:c919498-919238 [Staphylococcus aureus subsp. aureus ST772-MRSA-V]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT52767 NZ_CP010526:c919498-919238 [Staphylococcus aureus subsp. aureus ST772-MRSA-V]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References