52763

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 590345..590981 Replicon chromosome
Accession NZ_CP010524
Organism Bacillus paralicheniformis strain BL-09

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag SC10_RS02875 Protein ID WP_003179128.1
Coordinates 590631..590981 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag SC10_RS02870 Protein ID WP_006638778.1
Coordinates 590345..590626 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SC10_RS02850 585455..586939 + 1485 WP_043054080.1 PH domain-containing protein -
SC10_RS02855 586936..587535 - 600 WP_020450255.1 rhomboid family intramembrane serine protease -
SC10_RS02860 587879..588838 + 960 WP_165395380.1 outer membrane lipoprotein carrier protein LolA -
SC10_RS02865 589064..590233 + 1170 WP_023857864.1 alanine racemase -
SC10_RS02870 590345..590626 + 282 WP_006638778.1 hypothetical protein Antitoxin
SC10_RS02875 590631..590981 + 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
SC10_RS02880 591099..591926 + 828 WP_023857863.1 RsbT co-antagonist protein RsbRA -
SC10_RS02885 591930..592295 + 366 WP_031305225.1 STAS domain-containing protein -
SC10_RS02890 592298..592699 + 402 WP_023857861.1 anti-sigma regulatory factor -
SC10_RS02895 592710..593717 + 1008 WP_020450261.1 PP2C family protein-serine/threonine phosphatase -
SC10_RS02900 593776..594102 + 327 WP_020450262.1 anti-sigma factor antagonist -
SC10_RS02905 594102..594584 + 483 WP_020450263.1 anti-sigma B factor RsbW -
SC10_RS02910 594550..595341 + 792 WP_023857858.1 RNA polymerase sigma factor SigB -
SC10_RS02915 595338..595937 + 600 WP_023857857.1 SpoIIE family protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T52763 WP_003179128.1 NZ_CP010524:590631-590981 [Bacillus paralicheniformis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

>T52763 NZ_CP010524:590631-590981 [Bacillus paralicheniformis]
TTGATTGTTAAACGCGGCGATGTTTATTTTGCTGACCTATCTCCTGTTGTTGGCTCAGAACAAGGCGGGGTGCGCCCGGT
TTTAGTGATTCAAAACAACATCGGCAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CAAAATTACCTACCCACGTCGAAATTGATGCGAAACGCTACGGTTTTGAAAGAGATTCCGTTATATTGCTCGAACAAATT
CGGACGATTGACAAGCAAAGATTAACGGACAAAATCACCCATCTCGATGATGAAATGATGGAAAAGGTCAACGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT52763 WP_006638778.1 NZ_CP010524:590345-590626 [Bacillus paralicheniformis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp

>AT52763 NZ_CP010524:590345-590626 [Bacillus paralicheniformis]
TTGTCTGAATCCAGCGCAACAACTGAAATATTGATTCGCTTGCCAGAAGCTTTAGTATCAGAACTGGATGGTGTCGTCAT
GCAAGATAACGGGAGCAGAAATGAACTGATTTACCAAGCCACAAAAATGTATTTGCGCGAGCGCAAAAATCGACAAATTC
GGGAATCGATGAGACGCGGTTATATGGAGATGGCCAAGATTAATTTGAACATCTCTTCTGAGGCTCAATTTGCAGAGTAT
GAGGCTGAAAACACAGTAGAGCGCTTAGTAAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB M5PDU2

References