52742

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 48499..49169 Replicon chromosome
Accession NZ_CP010517
Organism Cupriavidus gilardii CR3

Toxin (Protein)


Gene name vapC Uniprot ID A0A0M3SWE7
Locus tag CR3_RS15945 Protein ID WP_053823293.1
Coordinates 48499..48918 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0M5KNN8
Locus tag CR3_RS15950 Protein ID WP_053823294.1
Coordinates 48915..49169 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CR3_RS15930 44633..45859 - 1227 WP_170265920.1 GDP-mannose 4,6-dehydratase -
CR3_RS15935 45846..47270 - 1425 WP_053823291.1 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase -
CR3_RS15940 47530..47865 - 336 WP_053823292.1 YXWGXW repeat-containing protein -
CR3_RS15945 48499..48918 - 420 WP_053823293.1 type II toxin-antitoxin system VapC family toxin Toxin
CR3_RS15950 48915..49169 - 255 WP_053823294.1 Arc family DNA-binding protein Antitoxin
CR3_RS15955 49397..50181 - 785 Protein_43 MFS transporter -
CR3_RS26380 50189..50686 - 498 WP_193392499.1 hypothetical protein -
CR3_RS15960 50692..51134 - 443 Protein_45 nucleoside deaminase -
CR3_RS15965 51218..52153 + 936 WP_082371668.1 LysR family transcriptional regulator -
CR3_RS15970 52173..53186 - 1014 WP_053824513.1 MBL fold metallo-hydrolase -
CR3_RS15975 53292..53810 - 519 WP_053823295.1 MarR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14787.84 Da        Isoelectric Point: 4.8605

>T52742 WP_053823293.1 NZ_CP010517:c48918-48499 [Cupriavidus gilardii CR3]
MIVLDTNVVSEAMKPAPNEAVRAWLNDQVAETLYVSSVTLAELLFGIGALPDGRRKQGLTEALDGVIALFGERILTFDTD
AARHYAESAVKARAAGKGFPTPDGYIAAIAASRGFIVATRDTSPFEAAGLTVINPWNRP

Download         Length: 420 bp

>T52742 NZ_CP010517:c48918-48499 [Cupriavidus gilardii CR3]
ATGATCGTACTCGACACGAATGTCGTCTCCGAGGCGATGAAGCCGGCACCCAACGAAGCGGTACGCGCCTGGCTAAACGA
TCAGGTCGCGGAAACCTTGTATGTGTCCAGCGTGACGCTGGCAGAACTGCTGTTCGGCATCGGAGCGCTCCCGGACGGGC
GACGCAAGCAAGGCTTGACGGAGGCATTGGACGGCGTGATCGCGCTGTTCGGTGAGCGGATATTGACGTTCGACACCGAT
GCCGCCCGGCACTATGCCGAATCGGCGGTCAAGGCAAGAGCAGCGGGCAAAGGCTTTCCGACACCCGACGGATATATTGC
GGCCATTGCCGCGTCGAGGGGATTTATCGTGGCGACCCGCGATACCAGCCCCTTCGAAGCAGCCGGACTCACTGTCATCA
ATCCCTGGAACCGGCCGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9525.87 Da        Isoelectric Point: 6.4725

>AT52742 WP_053823294.1 NZ_CP010517:c49169-48915 [Cupriavidus gilardii CR3]
MAILTIRNVPDEVHRALRMRAAVHGRSTEAEVRQILENAVMSEQRVRLGDALAEISRRVGLTNEDFAVLEQGRDKTPAEP
MRFE

Download         Length: 255 bp

>AT52742 NZ_CP010517:c49169-48915 [Cupriavidus gilardii CR3]
ATGGCTATCCTGACGATCCGAAATGTGCCAGACGAGGTGCACCGCGCCCTGCGCATGCGCGCCGCGGTCCACGGCCGCAG
CACCGAGGCAGAGGTACGACAAATACTGGAGAACGCTGTGATGTCGGAGCAACGTGTTCGGCTGGGTGACGCCTTGGCCG
AAATCAGCCGCCGAGTCGGACTGACAAACGAAGACTTCGCCGTGCTGGAGCAGGGACGCGATAAAACGCCAGCGGAGCCA
ATGAGGTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M3SWE7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M5KNN8

References