Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/GNAT-DUF1778
Location 829574..830352 Replicon chromosome
Accession NZ_CP010516
Organism Cupriavidus gilardii CR3

Toxin (Protein)


Gene name tacT Uniprot ID A0A0M4L1V5
Locus tag CR3_RS03660 Protein ID WP_053821302.1
Coordinates 829574..830077 (-) Length 168 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A0H4W2N5
Locus tag CR3_RS03665 Protein ID WP_029577227.1
Coordinates 830074..830352 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CR3_RS03630 826284..826508 - 225 WP_053821296.1 hypothetical protein -
CR3_RS03635 826505..826723 - 219 WP_053821297.1 hypothetical protein -
CR3_RS03640 826708..827436 - 729 WP_053821298.1 hypothetical protein -
CR3_RS03645 827458..827694 - 237 WP_144425749.1 hypothetical protein -
CR3_RS03650 827841..829130 + 1290 WP_144425876.1 recombinase family protein -
CR3_RS03655 829127..829558 + 432 WP_053821301.1 hypothetical protein -
CR3_RS03660 829574..830077 - 504 WP_053821302.1 GNAT family N-acetyltransferase Toxin
CR3_RS03665 830074..830352 - 279 WP_029577227.1 DUF1778 domain-containing protein Antitoxin
CR3_RS03670 831206..831880 - 675 WP_053821303.1 phosphoglycolate phosphatase -
CR3_RS03675 831883..832632 - 750 WP_053821304.1 bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG -
CR3_RS03680 832836..833498 - 663 WP_023265125.1 OmpA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(43-145)

Antitoxin

Vibrio phage ICP1, Orf50

(11-86)


Sequences

Toxin        


Download         Length: 168 a.a.        Molecular weight: 18409.16 Da        Isoelectric Point: 7.2632

>T52739 WP_053821302.1 NZ_CP010516:c830077-829574 [Cupriavidus gilardii CR3]
MSNDYSPVRKLAATDQVDAFDCGQAALNQFLQRYALVNQKANSAQTYVCCQGDVVVGFYSLAVGSVDPEATPSRVMKGLA
RHPVPVMILARLAVDKEHQRKGLGQALLKDALLRTAQAADIAGIRCLLVHAKDDAARQWYESWEFDPSPTDPYHLFLMLK
DLKGMLS

Download         Length: 504 bp

>T52739 NZ_CP010516:c830077-829574 [Cupriavidus gilardii CR3]
TTGAGCAATGACTACTCGCCCGTTCGCAAGCTGGCTGCAACGGATCAGGTCGATGCGTTCGACTGCGGCCAGGCCGCGCT
GAACCAGTTCCTGCAGCGCTACGCGCTCGTCAACCAGAAGGCCAACAGCGCGCAGACCTATGTCTGCTGCCAGGGTGACG
TGGTGGTCGGCTTCTACAGCCTAGCCGTTGGTAGCGTCGATCCGGAAGCCACGCCGTCGAGAGTGATGAAGGGGCTGGCG
CGCCACCCGGTGCCGGTCATGATCCTGGCCCGGCTCGCCGTGGACAAGGAGCATCAGCGTAAAGGTCTGGGCCAGGCCTT
GCTCAAGGATGCACTGCTGCGCACCGCACAGGCCGCCGACATTGCGGGTATCCGCTGCCTGTTGGTCCATGCCAAGGACG
ACGCAGCACGGCAGTGGTACGAATCGTGGGAATTCGACCCCAGCCCGACTGATCCGTACCATCTGTTCCTGATGCTCAAG
GATCTCAAAGGCATGTTGAGCTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10344.85 Da        Isoelectric Point: 9.2519

>AT52739 WP_029577227.1 NZ_CP010516:c830352-830074 [Cupriavidus gilardii CR3]
MSTLNLSKTERIDVRASTPVKQLLQEAARACHKNVSEFLLDAGVTAAAQTLADRRQFVLDDTQWQAFQEALDRPVQSKPR
LKKLLREPGVLD

Download         Length: 279 bp

>AT52739 NZ_CP010516:c830352-830074 [Cupriavidus gilardii CR3]
ATGAGCACCCTGAATCTTTCCAAGACCGAACGCATTGACGTTCGTGCCAGCACGCCGGTCAAGCAGCTGCTTCAAGAAGC
CGCACGCGCCTGCCACAAGAACGTCAGCGAGTTCCTGCTCGACGCGGGCGTGACGGCGGCCGCGCAGACGCTGGCGGATC
GTCGCCAGTTCGTGCTGGACGACACACAGTGGCAGGCCTTCCAGGAGGCGCTGGACCGCCCGGTGCAAAGCAAGCCGCGT
CTGAAGAAGTTGCTGCGTGAACCTGGGGTGCTGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4L1V5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H4W2N5

References