Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 997932..998578 Replicon chromosome
Accession NZ_CP010515
Organism Acidilobus sp. 7A

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SE86_RS04985 Protein ID WP_117354539.1
Coordinates 998189..998578 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag SE86_RS04980 Protein ID WP_117354538.1
Coordinates 997932..998192 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SE86_RS08250 993003..993299 - 297 WP_117354534.1 FAD-dependent oxidoreductase -
SE86_RS04960 (SE86_04890) 993474..993896 + 423 WP_117354535.1 SCP2 sterol-binding domain-containing protein -
SE86_RS04965 (SE86_04895) 993899..995062 - 1164 WP_148666783.1 iron-containing alcohol dehydrogenase -
SE86_RS04970 (SE86_04900) 995076..996797 - 1722 WP_117354537.1 thiamine pyrophosphate-binding protein -
SE86_RS04975 (SE86_04905) 997281..997706 + 426 WP_211096498.1 hypothetical protein -
SE86_RS04980 (SE86_04910) 997932..998192 + 261 WP_117354538.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SE86_RS04985 (SE86_04915) 998189..998578 + 390 WP_117354539.1 type II toxin-antitoxin system VapC family toxin Toxin
SE86_RS04990 (SE86_04920) 998747..999718 - 972 WP_211096499.1 dihydropteroate synthase -
SE86_RS04995 (SE86_04925) 999781..1001244 - 1464 WP_211096500.1 hypothetical protein -
SE86_RS05000 (SE86_04930) 1001244..1001456 - 213 WP_117354540.1 DUF3311 domain-containing protein -
SE86_RS05005 (SE86_04935) 1001578..1002810 + 1233 WP_211096501.1 M20 family metallopeptidase -
SE86_RS05010 1002807..1003316 - 510 WP_117354542.1 ParB N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

SpoVT-AbrB domain

(4-46)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14891.25 Da        Isoelectric Point: 4.6286

>T52738 WP_117354539.1 NZ_CP010515:998189-998578 [Acidilobus sp. 7A]
VIFVDANFLIYLNLGVKEIEGYYLKLLSEESLATNPLVLDEVIYVSKKKYGVRLEDTLDFLDNVVLPNSVVLPLTINEYR
RAREVMLKYSLNPSDALHVAVMLNNSIRRILSEDTDFDRVKEVERVWLG

Download         Length: 390 bp

>T52738 NZ_CP010515:998189-998578 [Acidilobus sp. 7A]
GTGATATTCGTGGACGCTAACTTCCTAATTTATCTCAACCTCGGCGTGAAGGAGATCGAGGGCTATTACCTGAAGCTCCT
GTCAGAGGAGTCCCTCGCCACCAACCCGCTTGTCCTGGACGAGGTAATTTATGTCTCTAAGAAAAAGTACGGCGTTAGGC
TTGAGGACACCTTAGACTTCCTAGATAACGTTGTGCTGCCAAACTCTGTAGTCCTTCCACTAACGATTAATGAGTACAGG
AGGGCCAGGGAGGTCATGTTAAAGTACTCGCTAAACCCCTCCGACGCGCTCCACGTGGCTGTGATGCTGAACAACTCCAT
AAGGAGGATCCTGAGCGAGGACACGGACTTCGACAGGGTTAAGGAGGTTGAGAGGGTCTGGCTGGGCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9799.36 Da        Isoelectric Point: 7.0198

>AT52738 WP_117354538.1 NZ_CP010515:997932-998192 [Acidilobus sp. 7A]
MTAKVEVGRKGYIIIPKSIRELIGIKEGDVLTLTVENGRIVLEPERRVSLPEVARRLREHEEKVRKYAKEARLGDLAGVS
LEDEFE

Download         Length: 261 bp

>AT52738 NZ_CP010515:997932-998192 [Acidilobus sp. 7A]
TTGACTGCAAAGGTAGAGGTCGGGAGGAAGGGCTACATAATAATTCCTAAGAGCATAAGGGAGCTGATTGGGATAAAGGA
GGGGGACGTGCTGACCTTGACCGTTGAGAATGGAAGGATAGTGCTGGAGCCGGAGAGGAGGGTCAGCCTGCCTGAGGTGG
CTAGGAGGCTCAGGGAGCACGAGGAGAAAGTGAGAAAGTACGCTAAGGAGGCCAGGCTGGGCGACCTCGCTGGCGTGAGC
CTAGAGGATGAGTTCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References