Detailed information of TA system TA052736

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/RelB(antitoxin)
• Location: 1342491..1343139
• Replicon: chromosome
• Accession: NZ_CP010453
• Organism: Bifidobacterium longum strain BG7

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: F8APW6
• Locus tag: BBG7_RS05855
• Protein ID: WP_014485576.1
• Coordinates: 1342491..1342850 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: F8APW5
• Locus tag: BBG7_RS05860
• Protein ID: WP_014485575.1
• Coordinates: 1342843..1343139 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BBG7_RS05835	1338347..1339252	-	906	WP_014485580.1	hypothetical protein	-
BBG7_RS05840	1339349..1340071	+	723	WP_014485579.1	hypothetical protein	-
BBG7_RS05845	1340119..1341654	+	1536	WP_014485578.1	cell division protein FtsZ	-
BBG7_RS05850	1341851..1342276	+	426	WP_026646092.1	hypothetical protein	-
BBG7_RS05855	1342491..1342850	-	360	WP_014485576.1	hypothetical protein	Toxin
BBG7_RS05860	1342843..1343139	-	297	WP_014485575.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BBG7_RS05865	1343644..1344405	-	762	WP_007056226.1	IS21-like element ISBlo2 family helper ATPase IstB	-
BBG7_RS05870	1344402..1345895	-	1494	WP_172673043.1	IS21 family transposase	-
BBG7_RS11415	1346893..1347030	+	138	WP_172673051.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1338347..1425647	87300

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• RelB antitoxin/Antitoxin DinJ (11-52)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13428.24 Da
• Isoelectric Point: 6.2247

>T52736 WP_014485576.1 NZ_CP010453:c1342850-1342491 [Bifidobacterium longum]
MHEPEVYDVWLMRVEFPDHPGVGKIRPVIVTRVEGDRVSGIVVKVTSVTTWNGPGDVPLLDWRQEGLYKPSVARCSQRFW
FGDGDLLKYFGRLSLRDANDLDAGLDATGDIPPHRQSRP

Nucleotide

• Length: 360 bp

>T52736 NZ_CP010453:c1342850-1342491 [Bifidobacterium longum]
ATGCATGAGCCCGAAGTATATGACGTGTGGCTGATGCGCGTCGAGTTCCCCGATCATCCCGGCGTGGGCAAGATCAGGCC
CGTCATCGTCACCAGGGTCGAGGGCGATCGGGTCTCGGGTATCGTCGTCAAGGTGACCAGTGTGACGACATGGAACGGTC
CGGGTGACGTGCCGTTGCTTGACTGGCGTCAGGAGGGCCTATACAAGCCATCCGTGGCGAGATGCTCGCAGCGTTTCTGG
TTTGGCGATGGTGACTTGTTGAAGTATTTCGGCAGGTTGTCGTTGCGCGACGCGAACGACCTTGATGCCGGTCTTGATGC
GACGGGTGACATTCCGCCTCACCGTCAGTCGCGTCCATGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11007.35 Da
• Isoelectric Point: 4.6556

>AT52736 WP_014485575.1 NZ_CP010453:c1343139-1342843 [Bifidobacterium longum]
MAVKERTTIALDPEVKREAADVLEQMGLSLSSFTEICLRQVVRDKGMPFTPSLRATRSDGYPVPPAHDAYRFERSKSTGN
IVLPQDWDDPADDIYDHA

Nucleotide

• Length: 297 bp

>AT52736 NZ_CP010453:c1343139-1342843 [Bifidobacterium longum]
ATGGCTGTGAAGGAACGGACGACCATTGCATTGGATCCCGAGGTCAAGCGTGAGGCGGCGGACGTGCTTGAGCAGATGGG
TTTGAGCCTGAGCTCATTCACGGAGATCTGTCTGCGGCAGGTGGTCCGCGACAAGGGCATGCCGTTCACACCGAGTCTGA
GGGCGACCCGATCCGATGGATATCCGGTTCCGCCGGCTCATGACGCGTATCGGTTCGAGCGTTCGAAGAGTACGGGCAAC
ATCGTACTGCCTCAGGACTGGGACGATCCGGCGGACGACATCTACGATCATGCATGA

Structures

Toxin

• AlphaFold DB: F8APW6

Antitoxin

• AlphaFold DB: F8APW5