Detailed information of TA system TA052735

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1547179..1547791
• Replicon: chromosome
• Accession: NZ_CP010450
• Organism: Streptococcus pyogenes strain NGAS638

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: SD90_RS07690
• Protein ID: WP_002994716.1
• Coordinates: 1547456..1547791 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: SD90_RS07685
• Protein ID: WP_002988079.1
• Coordinates: 1547179..1547466 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SD90_RS07660	1542370..1543353	-	984	WP_032463029.1	tagatose-bisphosphate aldolase	-
SD90_RS07665	1543357..1544286	-	930	WP_020837785.1	tagatose-6-phosphate kinase	-
SD90_RS07670	1544332..1544847	-	516	WP_002991700.1	galactose-6-phosphate isomerase subunit LacB	-
SD90_RS07675	1544882..1545310	-	429	WP_002991702.1	galactose-6-phosphate isomerase subunit LacA	-
SD90_RS07680	1545756..1546529	+	774	WP_023605292.1	DeoR/GlpR family DNA-binding transcription regulator	-
SD90_RS07685	1547179..1547466	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
SD90_RS07690	1547456..1547791	+	336	WP_002994716.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SD90_RS09390	1547943..1548413	+	471	WP_021733374.1	site-specific integrase	-
SD90_RS09395	1548376..1548924	+	549	WP_194088157.1	site-specific integrase	-
SD90_RS07700	1549045..1549437	-	393	WP_002982716.1	30S ribosomal protein S9	-
SD90_RS07705	1549458..1549904	-	447	WP_002982710.1	50S ribosomal protein L13	-
SD90_RS07710	1550122..1550328	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
SD90_RS07715	1550325..1550831	-	507	WP_002988070.1	hypothetical protein	-
SD90_RS07720	1550967..1551827	-	861	WP_002982687.1	DegV family protein	-
SD90_RS07725	1551924..1552442	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-104)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13154.89 Da
• Isoelectric Point: 5.6157

>T52735 WP_002994716.1 NZ_CP010450:1547456-1547791 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Nucleotide

• Length: 336 bp

>T52735 NZ_CP010450:1547456-1547791 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCATAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCTGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT52735 WP_002988079.1 NZ_CP010450:1547179-1547466 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT52735 NZ_CP010450:1547179-1547466 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A4U7GX94