Detailed information of TA system TA052734

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1714510..1715122
• Replicon: chromosome
• Accession: NZ_CP010449
• Organism: Streptococcus pyogenes strain NGAS322

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: SD89_RS08605
• Protein ID: WP_053308617.1
• Coordinates: 1714787..1715122 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: SD89_RS08600
• Protein ID: WP_002988079.1
• Coordinates: 1714510..1714797 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SD89_RS08565	1709829..1710812	-	984	WP_053308611.1	tagatose-bisphosphate aldolase	-
SD89_RS08570	1710816..1711745	-	930	WP_053308612.1	tagatose-6-phosphate kinase	-
SD89_RS08575	1711791..1712306	-	516	WP_053308613.1	galactose-6-phosphate isomerase subunit LacB	-
SD89_RS08580	1712341..1712769	-	429	WP_053308614.1	galactose-6-phosphate isomerase subunit LacA	-
SD89_RS08590	1713215..1713988	+	774	WP_011285171.1	DeoR/GlpR family DNA-binding transcription regulator	-
SD89_RS10345	1714126..1714290	-	165	WP_195834039.1	hypothetical protein	-
SD89_RS08600	1714510..1714797	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
SD89_RS08605	1714787..1715122	+	336	WP_053308617.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SD89_RS10350	1715249..1715743	+	495	Protein_1653	tyrosine-type recombinase/integrase family protein	-
SD89_RS10355	1715857..1716207	+	351	WP_111679863.1	tyrosine-type recombinase/integrase	-
SD89_RS08610	1716375..1716767	-	393	WP_002982716.1	30S ribosomal protein S9	-
SD89_RS08615	1716788..1717234	-	447	WP_002982710.1	50S ribosomal protein L13	-
SD89_RS08620	1717452..1717658	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
SD89_RS08625	1717655..1718353	-	699	WP_023610631.1	hypothetical protein	-
SD89_RS08630	1718489..1719349	-	861	WP_002982687.1	DegV family protein	-
SD89_RS08635	1719446..1719964	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13175.91 Da
• Isoelectric Point: 5.2144

>T52734 WP_053308617.1 NZ_CP010449:1714787-1715122 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSSQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T52734 NZ_CP010449:1714787-1715122 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAAGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT52734 WP_002988079.1 NZ_CP010449:1714510-1714797 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT52734 NZ_CP010449:1714510-1714797 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A4U7GX94