Detailed information of TA system TA052412

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 302451..303022
• Replicon: chromosome
• Accession: NZ_CP010437
• Organism: Bifidobacterium adolescentis strain BB23

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BBMN23_RS01155
• Protein ID: WP_003807675.1
• Coordinates: 302451..302750 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0C2Z6P7
• Locus tag: BBMN23_RS01160
• Protein ID: WP_034984155.1
• Coordinates: 302750..303022 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BBMN23_RS01145	299116..299844	+	729	WP_003807670.1	type 1 glutamine amidotransferase	-
BBMN23_RS01150	300156..302354	+	2199	WP_039774710.1	ABC-F family ATP-binding cassette domain-containing protein	-
BBMN23_RS01155	302451..302750	-	300	WP_003807675.1	type II toxin-antitoxin system YafQ family toxin	Toxin
BBMN23_RS01160	302750..303022	-	273	WP_034984155.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BBMN23_RS01165	303136..303972	-	837	WP_039774711.1	hypothetical protein	-
BBMN23_RS01170	304156..304695	+	540	WP_003807679.1	hypothetical protein	-
BBMN23_RS09440	304688..305206	+	519	WP_130082043.1	hypothetical protein	-
BBMN23_RS01175	305265..306419	-	1155	WP_046998989.1	ATP-binding protein	-
BBMN23_RS01180	306422..307051	-	630	WP_039774712.1	response regulator transcription factor	-
BBMN23_RS01185	307188..307829	+	642	WP_039774713.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-98)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-69)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11662.09 Da
• Isoelectric Point: 8.0955

>T52412 WP_003807675.1 NZ_CP010437:c302750-302451 [Bifidobacterium adolescentis]
MGRLTADFAKAFSRDLKKNAKRRNWNLTELEKVIDLVVENTPETLEELRRRHNMHTLSGNWRGRYECHVANAGDWLVIWS
SNDSVAFFERTGSHDELFR

Nucleotide

• Length: 300 bp

>T52412 NZ_CP010437:c302750-302451 [Bifidobacterium adolescentis]
ATGGGCCGGTTGACCGCCGACTTCGCGAAGGCCTTCAGCCGCGATCTGAAAAAGAACGCCAAACGGCGTAACTGGAACCT
GACCGAGCTTGAAAAAGTCATCGATCTGGTAGTGGAGAACACCCCGGAAACGCTGGAGGAGCTGCGCCGCCGCCACAACA
TGCACACCCTGTCCGGCAATTGGCGCGGGCGATACGAATGCCATGTCGCCAATGCCGGGGACTGGCTAGTGATCTGGTCA
TCGAACGATTCAGTCGCATTCTTCGAACGCACCGGCAGCCACGACGAATTATTCCGGTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9714.91 Da
• Isoelectric Point: 4.5535

>AT52412 WP_034984155.1 NZ_CP010437:c303022-302750 [Bifidobacterium adolescentis]
MSASTLTIRMDDELKRSAADVAEYYGLDLSSVVRAVFKQMVNTGRIPLTFAPEEPNGESLNAAAEADSFMASGKTGRFTN
GHDLLEAAMR

Nucleotide

• Length: 273 bp

>AT52412 NZ_CP010437:c303022-302750 [Bifidobacterium adolescentis]
ATGAGTGCATCAACGTTGACCATACGGATGGATGACGAACTCAAGCGTTCGGCCGCCGACGTGGCCGAATATTATGGCTT
GGATCTCTCGTCAGTGGTGCGCGCCGTATTCAAGCAAATGGTGAATACCGGGCGCATCCCATTGACGTTCGCCCCCGAGG
AGCCTAATGGCGAAAGCCTGAACGCCGCTGCCGAAGCGGACAGCTTCATGGCATCGGGCAAGACGGGGCGTTTTACCAAC
GGACACGACCTGCTCGAAGCGGCGATGCGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0C2Z6P7