Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3886030..3886640 Replicon chromosome
Accession NZ_CP010423
Organism Pragia fontium strain 24613

Toxin (Protein)


Gene name doc Uniprot ID A0A0G3CNG1
Locus tag QQ39_RS16925 Protein ID WP_047782255.1
Coordinates 3886248..3886640 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0G3CU99
Locus tag QQ39_RS16920 Protein ID WP_047782254.1
Coordinates 3886030..3886251 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ39_RS16900 3881954..3882595 + 642 WP_053007677.1 hypothetical protein -
QQ39_RS16905 3882915..3883778 + 864 WP_047782251.1 hypothetical protein -
QQ39_RS16910 3883778..3884149 + 372 WP_047782252.1 MarR family transcriptional regulator -
QQ39_RS16915 3884394..3885425 + 1032 WP_047782253.1 retron St85 family RNA-directed DNA polymerase -
QQ39_RS16920 3886030..3886251 + 222 WP_047782254.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QQ39_RS16925 3886248..3886640 + 393 WP_047782255.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
QQ39_RS16935 3887458..3888204 + 747 WP_047782256.1 ferredoxin--NADP(+) reductase -
QQ39_RS16940 3888365..3889030 + 666 WP_053007678.1 DUF1454 family protein -
QQ39_RS16945 3889196..3889966 + 771 WP_047782257.1 triose-phosphate isomerase -
QQ39_RS16950 3890038..3891000 - 963 WP_047782258.1 6-phosphofructokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14736.80 Da        Isoelectric Point: 6.4808

>T52396 WP_047782255.1 NZ_CP010423:3886248-3886640 [Pragia fontium]
MIWISAQEVIAFHDRILQRLPGVAGMSDPGRAEALIYRVQNRTHNEGVTDVFELAATYWVAIARGHIFNDCNKRTAFFVT
MTFLYRNGIKIRDDDNTLENLTVEAATGEKTVDQLAQHLRGLVDYIGLVR

Download         Length: 393 bp

>T52396 NZ_CP010423:3886248-3886640 [Pragia fontium]
ATGATATGGATCAGCGCGCAAGAAGTTATCGCTTTCCATGACCGTATATTGCAGCGACTTCCCGGCGTTGCAGGCATGTC
GGATCCCGGCAGAGCTGAAGCACTGATCTACCGGGTACAAAACCGTACTCACAATGAAGGCGTTACGGATGTTTTTGAAT
TGGCGGCTACTTACTGGGTAGCTATCGCTCGTGGCCATATATTTAATGACTGCAATAAGCGCACTGCGTTTTTTGTTACT
ATGACTTTTCTCTACCGCAACGGTATCAAGATTCGTGATGACGACAATACGCTGGAAAACTTAACGGTAGAAGCTGCTAC
TGGGGAGAAAACTGTTGATCAGTTAGCTCAGCATTTGCGTGGATTAGTAGACTATATTGGCCTAGTTCGTTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8121.97 Da        Isoelectric Point: 5.5675

>AT52396 WP_047782254.1 NZ_CP010423:3886030-3886251 [Pragia fontium]
MRTYTSTQARANISEVLDAATHGEPVEITRRDGSSAVVISKAEFESYQNAKLDAEFDVIMQRHGHTVEALTNR

Download         Length: 222 bp

>AT52396 NZ_CP010423:3886030-3886251 [Pragia fontium]
ATGCGTACATACACCTCAACCCAAGCCCGCGCCAATATCTCAGAAGTACTGGATGCAGCTACCCACGGAGAACCAGTTGA
AATCACCCGCAGAGACGGTAGCTCAGCGGTAGTTATCAGCAAGGCTGAATTCGAGTCATATCAGAATGCTAAGCTAGATG
CAGAATTTGATGTGATTATGCAACGTCATGGACACACGGTCGAGGCACTGACAAACCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G3CNG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3CU99

References