Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prpT-prpA/ParE-CC2985
Location 1587022..1587571 Replicon chromosome
Accession NZ_CP010423
Organism Pragia fontium strain 24613

Toxin (Protein)


Gene name PrpT Uniprot ID A0A0G3CIR5
Locus tag QQ39_RS07090 Protein ID WP_047780618.1
Coordinates 1587266..1587571 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name PrpA Uniprot ID A0A0G3CPL6
Locus tag QQ39_RS07085 Protein ID WP_047780617.1
Coordinates 1587022..1587279 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ39_RS07065 1582710..1584245 - 1536 WP_047780613.1 apolipoprotein N-acyltransferase -
QQ39_RS18845 1584253..1585131 - 879 WP_047780614.1 CNNM family magnesium/cobalt transport protein CorC -
QQ39_RS18850 1585150..1585623 - 474 WP_047780615.1 rRNA maturation RNase YbeY -
QQ39_RS07080 1585636..1586691 - 1056 WP_047780616.1 PhoH family protein -
QQ39_RS07085 1587022..1587279 + 258 WP_047780617.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
QQ39_RS07090 1587266..1587571 + 306 WP_047780618.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QQ39_RS07095 1587664..1589088 - 1425 WP_047780619.1 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB -
QQ39_RS07100 1589247..1590437 + 1191 WP_047780620.1 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-95)

Antitoxin

Antitoxin ParD

(4-74)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11940.92 Da        Isoelectric Point: 9.5270

>T52395 WP_047780618.1 NZ_CP010423:1587266-1587571 [Pragia fontium]
MLKSKEVRLTPKAISDLENIYRYSHREFGQIKAERYIRCIDAALNKLADFPQLGIHYFHLAKDLMGYKVESHIVFYRVRH
DVISVLRVLHKSMDYAEYIPG

Download         Length: 306 bp

>T52395 NZ_CP010423:1587266-1587571 [Pragia fontium]
ATGCTGAAAAGTAAAGAGGTACGCTTAACGCCAAAAGCGATTAGCGATCTGGAAAATATTTATAGGTATAGCCATCGAGA
ATTTGGCCAGATTAAAGCAGAACGATATATCAGGTGTATTGATGCTGCTTTGAATAAATTGGCTGATTTTCCTCAGTTAG
GCATTCACTATTTTCATTTGGCTAAAGATTTGATGGGTTATAAGGTTGAGTCTCATATCGTCTTTTATCGTGTACGGCAT
GATGTAATTTCGGTATTACGGGTGCTGCATAAATCGATGGATTATGCAGAATACATCCCTGGATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9748.01 Da        Isoelectric Point: 4.4764

>AT52395 WP_047780617.1 NZ_CP010423:1587022-1587279 [Pragia fontium]
MARTMTITPGEELRQFVEGLVEAGIYQTNSEVVREGLRMLQEKYAASQLTLLRQLIDEGEQSGEAVTWNSQDFIRRMNQL
KDAEK

Download         Length: 258 bp

>AT52395 NZ_CP010423:1587022-1587279 [Pragia fontium]
ATGGCACGCACAATGACCATCACCCCAGGAGAAGAATTGCGCCAATTCGTTGAAGGGCTCGTGGAAGCGGGCATTTATCA
AACTAACAGTGAAGTAGTTCGTGAGGGACTTCGGATGTTACAGGAAAAATATGCGGCTTCGCAGCTGACGCTTCTGCGCC
AATTAATTGATGAAGGTGAGCAAAGCGGTGAGGCTGTGACGTGGAATAGTCAGGACTTTATACGCAGGATGAATCAATTA
AAGGATGCTGAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G3CIR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3CPL6

References