Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1443108..1443661 Replicon chromosome
Accession NZ_CP010423
Organism Pragia fontium strain 24613

Toxin (Protein)


Gene name ccdB Uniprot ID A0A0G3CRI7
Locus tag QQ39_RS06190 Protein ID WP_047780464.1
Coordinates 1443353..1443661 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A0G3CXA9
Locus tag QQ39_RS06185 Protein ID WP_047782549.1
Coordinates 1443108..1443350 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ39_RS06170 1438652..1440460 + 1809 WP_047780461.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -
QQ39_RS06175 1440460..1442169 + 1710 WP_047780462.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
QQ39_RS06180 1442179..1442913 + 735 WP_047780463.1 phosphoadenylyl-sulfate reductase -
QQ39_RS06185 1443108..1443350 + 243 WP_047782549.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
QQ39_RS06190 1443353..1443661 + 309 WP_047780464.1 CcdB family protein Toxin
QQ39_RS06195 1444048..1445478 + 1431 WP_047780465.1 siroheme synthase CysG -
QQ39_RS06200 1445511..1446419 + 909 WP_047782550.1 sulfate adenylyltransferase subunit CysD -
QQ39_RS06205 1446460..1447887 + 1428 WP_047782551.1 sulfate adenylyltransferase subunit CysN -
QQ39_RS06210 1447894..1448490 + 597 WP_047780466.1 adenylyl-sulfate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(10-80)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11729.51 Da        Isoelectric Point: 6.4794

>T52394 WP_047780464.1 NZ_CP010423:1443353-1443661 [Pragia fontium]
MQYAVYRHAGNSKDYPYLLNIQSDLIGALNTRLVIPLFPLNRFTGNRPQYLCPVLHIENSDFLVMTHEMASVRQTMLGEV
VCHVDHHRDEIKAAIDFLIDGF

Download         Length: 309 bp

>T52394 NZ_CP010423:1443353-1443661 [Pragia fontium]
ATGCAATATGCCGTTTATCGTCATGCTGGAAACAGTAAAGATTATCCCTATTTATTGAATATACAGAGCGACTTAATTGG
TGCGCTTAATACTCGGTTAGTCATTCCACTTTTTCCACTAAATCGATTTACAGGAAACAGACCGCAATATCTGTGTCCTG
TACTCCACATTGAAAATAGTGATTTTTTAGTGATGACCCATGAAATGGCCAGCGTAAGACAAACGATGCTTGGTGAAGTT
GTTTGTCACGTTGATCATCACAGGGACGAGATTAAAGCGGCGATTGATTTTTTAATTGATGGATTTTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9175.32 Da        Isoelectric Point: 6.9764

>AT52394 WP_047782549.1 NZ_CP010423:1443108-1443350 [Pragia fontium]
MSVTHAKTTKKTVSVTLDPDLYQRARDMGINFSALLTQAVEQQLQAASRAQWQRDNQQAMEELNRITERCGLLSDEYRAF

Download         Length: 243 bp

>AT52394 NZ_CP010423:1443108-1443350 [Pragia fontium]
ATGTCAGTAACCCATGCCAAAACAACCAAAAAGACAGTGAGTGTCACTTTAGATCCCGATTTATATCAACGGGCTCGCGA
TATGGGCATTAACTTCTCAGCATTATTAACTCAGGCCGTTGAGCAGCAATTGCAGGCGGCATCAAGGGCTCAGTGGCAAC
GAGATAATCAGCAGGCAATGGAAGAGCTCAATCGTATTACTGAGCGGTGTGGGCTGCTCTCTGATGAATATCGAGCGTTT
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G3CRI7

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3CXA9

References