Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-YefM
Location 206939..207606 Replicon plasmid pAcX50f
Accession NZ_CP010421
Organism Azotobacter chroococcum NCIMB 8003

Toxin (Protein)


Gene name vapC Uniprot ID A0A4V5PSQ5
Locus tag Achr_RS22905 Protein ID WP_040107414.1
Coordinates 207190..207606 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0C4WT37
Locus tag Achr_RS22900 Protein ID WP_040107413.1
Coordinates 206939..207190 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Achr_RS22890 202669..206001 - 3333 WP_040107411.1 STY4851/ECs_5259 family protein -
Achr_RS22895 206320..206763 + 444 WP_040107412.1 hypothetical protein -
Achr_RS22900 206939..207190 + 252 WP_040107413.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
Achr_RS22905 207190..207606 + 417 WP_040107414.1 type II toxin-antitoxin system VapC family toxin Toxin
Achr_RS22910 207784..208173 - 390 WP_082045705.1 hypothetical protein -
Achr_RS22915 208431..208880 + 450 WP_040107266.1 DUF2384 domain-containing protein -
Achr_RS22920 208877..209314 + 438 WP_040107416.1 RES family NAD+ phosphorylase -
Achr_RS22925 209325..209720 + 396 WP_040107417.1 hypothetical protein -
Achr_RS24770 209825..210118 + 294 WP_082045675.1 hypothetical protein -
Achr_RS22930 210241..210513 - 273 WP_040107418.1 HU family DNA-binding protein -
Achr_RS22935 210567..210806 - 240 WP_040107517.1 hypothetical protein -
Achr_RS22940 211402..211974 - 573 WP_158319698.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..311724 311724


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(4-60)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14971.41 Da        Isoelectric Point: 7.2792

>T52390 WP_040107414.1 NZ_CP010421:207190-207606 [Azotobacter chroococcum NCIMB 8003]
MFLLDTNVVSELRKAKQGKADAGVVAWAQSVQVGELYLSAISVMELETGVLLRERKDPAQGALLRAWLDQHVLPGFAGRI
LAVDTAVALRCARLHVPNQKSERDALIAATALVHGMTVVTRNVADFEQTGVAMLNPWI

Download         Length: 417 bp

>T52390 NZ_CP010421:207190-207606 [Azotobacter chroococcum NCIMB 8003]
ATGTTCTTGCTCGATACCAATGTTGTCTCCGAGCTGCGCAAGGCCAAGCAGGGCAAGGCCGATGCCGGTGTTGTCGCTTG
GGCGCAAAGCGTCCAAGTCGGGGAGTTGTACCTGTCGGCCATTTCCGTGATGGAGCTGGAAACCGGGGTATTGCTGCGTG
AACGAAAGGATCCGGCTCAAGGGGCGCTTCTGCGAGCGTGGCTCGATCAGCATGTCCTTCCTGGCTTTGCCGGACGCATT
CTGGCAGTGGATACCGCCGTGGCTCTCCGGTGCGCGAGGCTGCATGTGCCGAATCAGAAGAGCGAGCGCGATGCGCTCAT
TGCCGCGACGGCGCTCGTTCACGGCATGACGGTCGTGACCCGGAACGTGGCGGATTTCGAGCAGACAGGCGTTGCAATGC
TCAACCCCTGGATTTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9100.39 Da        Isoelectric Point: 6.4559

>AT52390 WP_040107413.1 NZ_CP010421:206939-207190 [Azotobacter chroococcum NCIMB 8003]
MPTTLSSREFNHDTSRAKKAALTGPVFITDRGKPAHVLLCIEEYQRLTGSQPSIIDILAMPGGEDVEFEAPRATIKTKPV
DFS

Download         Length: 252 bp

>AT52390 NZ_CP010421:206939-207190 [Azotobacter chroococcum NCIMB 8003]
ATGCCGACGACCCTTTCTAGCCGGGAGTTCAATCACGACACCAGCCGGGCAAAGAAGGCCGCGCTGACCGGGCCTGTGTT
CATCACAGATCGCGGGAAACCGGCTCACGTTCTGCTGTGCATCGAAGAATATCAGCGACTGACCGGCAGCCAACCCAGCA
TCATCGACATCCTGGCGATGCCAGGGGGAGAGGATGTGGAGTTTGAAGCCCCTCGCGCCACTATCAAGACGAAGCCGGTG
GATTTTTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4V5PSQ5

Antitoxin

Source ID Structure
AlphaFold DB A0A0C4WT37

References