Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | chpSB/PRK09812-MazE |
| Location | 151699..152297 | Replicon | plasmid pAcX50f |
| Accession | NZ_CP010421 | ||
| Organism | Azotobacter chroococcum NCIMB 8003 | ||
Toxin (Protein)
| Gene name | chpB | Uniprot ID | A0A0C4WLZ2 |
| Locus tag | Achr_RS22640 | Protein ID | WP_040107378.1 |
| Coordinates | 151950..152297 (+) | Length | 116 a.a. |
Antitoxin (Protein)
| Gene name | chpS | Uniprot ID | A0A0C4WXY8 |
| Locus tag | Achr_RS22635 | Protein ID | WP_040107377.1 |
| Coordinates | 151699..151953 (+) | Length | 85 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| Achr_RS22600 | 147632..147811 | + | 180 | WP_040107237.1 | hypothetical protein | - |
| Achr_RS22605 | 147792..148301 | + | 510 | WP_040107236.1 | hypothetical protein | - |
| Achr_RS22610 | 148406..148690 | + | 285 | WP_040107235.1 | hypothetical protein | - |
| Achr_RS22615 | 148841..149314 | + | 474 | WP_040107373.1 | hypothetical protein | - |
| Achr_RS22620 | 149301..150341 | + | 1041 | WP_040107374.1 | YqaJ viral recombinase family protein | - |
| Achr_RS22625 | 150568..150915 | + | 348 | WP_040107375.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| Achr_RS22630 | 150912..151256 | + | 345 | WP_040107376.1 | helix-turn-helix domain-containing protein | - |
| Achr_RS22635 | 151699..151953 | + | 255 | WP_040107377.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| Achr_RS22640 | 151950..152297 | + | 348 | WP_040107378.1 | type II toxin-antitoxin system ChpB family toxin | Toxin |
| Achr_RS22645 | 152311..152553 | + | 243 | WP_040107379.1 | hypothetical protein | - |
| Achr_RS22650 | 152697..152888 | + | 192 | WP_040107380.1 | hypothetical protein | - |
| Achr_RS22655 | 152904..153122 | + | 219 | WP_040107381.1 | hypothetical protein | - |
| Achr_RS22660 | 153304..153543 | + | 240 | WP_040107382.1 | hypothetical protein | - |
| Achr_RS22665 | 153560..153874 | + | 315 | WP_040107383.1 | hypothetical protein | - |
| Achr_RS22670 | 154136..154393 | + | 258 | WP_052264093.1 | hypothetical protein | - |
| Achr_RS22675 | 154478..155563 | + | 1086 | WP_039807303.1 | IS5 family transposase | - |
| Achr_RS22680 | 155754..155939 | + | 186 | WP_040107384.1 | hypothetical protein | - |
| Achr_RS22685 | 155958..156239 | + | 282 | WP_040107385.1 | hypothetical protein | - |
| Achr_RS22690 | 156361..156912 | - | 552 | WP_039803510.1 | transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..311724 | 311724 | |
| - | flank | IS/Tn | - | - | 154457..155563 | 1106 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 116 a.a. Molecular weight: 12252.83 Da Isoelectric Point: 7.2026
>T52388 WP_040107378.1 NZ_CP010421:151950-152297 [Azotobacter chroococcum NCIMB 8003]
VRRSQYGRGDIVRLNLNPTAGREQQGDFRPALILTPAAYNATGLAVIAPITQGGDHARYAGFAVTLSGAGTETQGVILTN
QIRSVDLEARGAKRVESVPEVVIEDALARVHALFE
VRRSQYGRGDIVRLNLNPTAGREQQGDFRPALILTPAAYNATGLAVIAPITQGGDHARYAGFAVTLSGAGTETQGVILTN
QIRSVDLEARGAKRVESVPEVVIEDALARVHALFE
Download Length: 348 bp
>T52388 NZ_CP010421:151950-152297 [Azotobacter chroococcum NCIMB 8003]
GTGAGGCGATCCCAGTACGGTCGAGGCGATATTGTCCGCCTGAACCTGAACCCAACGGCGGGCCGTGAGCAGCAGGGCGA
TTTTCGTCCGGCCTTGATCCTCACGCCAGCGGCGTACAACGCAACCGGCTTGGCCGTGATCGCGCCGATCACACAAGGCG
GCGACCATGCACGATATGCAGGGTTCGCGGTCACGCTGAGCGGAGCAGGGACAGAGACGCAGGGTGTGATCCTGACCAAC
CAGATTCGTTCTGTTGATCTTGAGGCTCGCGGGGCCAAGCGGGTGGAGTCGGTGCCCGAAGTGGTTATTGAAGATGCGCT
GGCCCGAGTCCATGCGCTATTTGAATAA
GTGAGGCGATCCCAGTACGGTCGAGGCGATATTGTCCGCCTGAACCTGAACCCAACGGCGGGCCGTGAGCAGCAGGGCGA
TTTTCGTCCGGCCTTGATCCTCACGCCAGCGGCGTACAACGCAACCGGCTTGGCCGTGATCGCGCCGATCACACAAGGCG
GCGACCATGCACGATATGCAGGGTTCGCGGTCACGCTGAGCGGAGCAGGGACAGAGACGCAGGGTGTGATCCTGACCAAC
CAGATTCGTTCTGTTGATCTTGAGGCTCGCGGGGCCAAGCGGGTGGAGTCGGTGCCCGAAGTGGTTATTGAAGATGCGCT
GGCCCGAGTCCATGCGCTATTTGAATAA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9047.54 Da Isoelectric Point: 6.2344
>AT52388 WP_040107377.1 NZ_CP010421:151699-151953 [Azotobacter chroococcum NCIMB 8003]
MEVKIQQWGNSAAIRLPATVLKQMSLASGDVLSLDVTGEAITLKPAKVKPRYKLADLMAQCDLNAPEPAELAAWNSMQPV
GREA
MEVKIQQWGNSAAIRLPATVLKQMSLASGDVLSLDVTGEAITLKPAKVKPRYKLADLMAQCDLNAPEPAELAAWNSMQPV
GREA
Download Length: 255 bp
>AT52388 NZ_CP010421:151699-151953 [Azotobacter chroococcum NCIMB 8003]
ATGGAAGTCAAGATTCAGCAATGGGGTAATAGTGCGGCGATTCGCTTGCCGGCGACGGTCCTCAAGCAAATGAGCCTCGC
CAGTGGCGACGTGCTCAGCCTCGATGTGACTGGCGAGGCGATCACCTTGAAGCCGGCGAAGGTCAAGCCGCGCTACAAGC
TGGCTGACCTGATGGCGCAATGCGACCTGAACGCGCCGGAGCCGGCAGAGCTGGCAGCCTGGAACTCGATGCAGCCGGTG
GGGCGTGAAGCGTGA
ATGGAAGTCAAGATTCAGCAATGGGGTAATAGTGCGGCGATTCGCTTGCCGGCGACGGTCCTCAAGCAAATGAGCCTCGC
CAGTGGCGACGTGCTCAGCCTCGATGTGACTGGCGAGGCGATCACCTTGAAGCCGGCGAAGGTCAAGCCGCGCTACAAGC
TGGCTGACCTGATGGCGCAATGCGACCTGAACGCGCCGGAGCCGGCAGAGCTGGCAGCCTGGAACTCGATGCAGCCGGTG
GGGCGTGAAGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0C4WLZ2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0C4WXY8 |