52384

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prcAT/RES-TIGR02293
Location 353..1236 Replicon plasmid pAcX50f
Accession NZ_CP010421
Organism Azotobacter chroococcum NCIMB 8003

Toxin (Protein)


Gene name PrcT Uniprot ID A0A0C4WUV3
Locus tag Achr_RS21855 Protein ID WP_040107267.1
Coordinates 799..1236 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name PrcA Uniprot ID A0A0C4WTA4
Locus tag Achr_RS21850 Protein ID WP_040107266.1
Coordinates 353..802 (+) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Achr_RS21850 353..802 + 450 WP_040107266.1 DUF2384 domain-containing protein Antitoxin
Achr_RS21855 799..1236 + 438 WP_040107267.1 RES family NAD+ phosphorylase Toxin
Achr_RS21860 1247..1642 + 396 WP_040107268.1 hypothetical protein -
Achr_RS21865 2093..2839 + 747 WP_040107269.1 SDR family oxidoreductase -
Achr_RS21870 3005..4090 + 1086 WP_082045547.1 IS5 family transposase -
Achr_RS21875 4296..4694 + 399 WP_040107270.1 hypothetical protein -
Achr_RS21880 4821..5093 + 273 WP_040107271.1 HU family DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..311724 311724
- flank IS/Tn - - 2984..4090 1106


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-140)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(97-143)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15768.06 Da        Isoelectric Point: 5.1405

>T52384 WP_040107267.1 NZ_CP010421:799-1236 [Azotobacter chroococcum NCIMB 8003]
VILWRISAYADLSGIGGLRASGRWHHLGRPVVYAADSPAGAMLEVLVHLEIDPEDFPATLQLIRIELPDPVSRVELAPLP
EHWKSGPEVTRATGDQFLDGRSALLLPVPSAIIPCTTNYLFNPAHPEASGASIQAEKFPFDSRLL

Download         Length: 438 bp

>T52384 NZ_CP010421:799-1236 [Azotobacter chroococcum NCIMB 8003]
GTGATTTTGTGGCGGATCAGTGCCTACGCCGACCTCAGCGGAATCGGCGGCCTGCGCGCCAGTGGCCGGTGGCACCACCT
TGGCAGGCCGGTCGTTTACGCGGCGGACAGCCCGGCCGGGGCGATGCTGGAGGTGCTGGTCCACCTGGAAATCGACCCCG
AGGACTTCCCGGCGACGCTGCAGTTGATCCGCATCGAGCTTCCGGACCCGGTTTCGCGGGTCGAGCTTGCGCCGCTGCCG
GAGCACTGGAAGTCTGGCCCGGAAGTCACGCGCGCAACGGGTGATCAGTTCCTCGATGGGCGAAGCGCTCTGCTGCTCCC
GGTGCCGAGCGCCATCATTCCCTGCACGACCAACTACCTGTTCAATCCGGCGCACCCCGAGGCCAGTGGGGCGAGCATCC
AAGCAGAGAAATTCCCCTTCGATTCCCGTCTCCTCTGA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16978.55 Da        Isoelectric Point: 6.7345

>AT52384 WP_040107266.1 NZ_CP010421:353-802 [Azotobacter chroococcum NCIMB 8003]
MLAEVLRDHGYTAYRARLQSLLDIPESATDFEIHTRITKGFPATRLVQLTEAGVVTPLERDQIIPLRTLKSRIERDQPLT
VEESDRFFRAAHITAMAEAVFGDREKARRWLSKPKERFAGLTPMQMLTTQQGTSQVEEMLLQIVEGLAL

Download         Length: 450 bp

>AT52384 NZ_CP010421:353-802 [Azotobacter chroococcum NCIMB 8003]
ATGCTTGCTGAAGTCCTGCGTGACCATGGCTACACCGCATACCGGGCACGTCTTCAAAGCCTGCTGGACATCCCGGAGTC
GGCAACCGACTTCGAGATCCACACCCGGATCACCAAGGGCTTTCCTGCAACCCGCCTGGTGCAGCTGACCGAGGCGGGAG
TGGTTACGCCGCTGGAGCGCGACCAGATCATTCCCCTGCGCACCCTCAAGAGCCGCATCGAGCGCGATCAGCCGTTGACC
GTGGAGGAAAGCGACAGGTTCTTTCGCGCCGCCCACATCACGGCGATGGCCGAAGCCGTCTTCGGCGACCGCGAGAAGGC
CAGGCGCTGGCTCTCCAAACCCAAGGAGCGGTTTGCCGGCCTGACGCCCATGCAGATGCTGACCACCCAGCAGGGCACCA
GCCAGGTGGAGGAAATGCTGCTGCAGATCGTTGAGGGCCTGGCCCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C4WUV3

Antitoxin

Source ID Structure
AlphaFold DB A0A0C4WTA4

References