Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 38007..38535 Replicon plasmid pAcX50c
Accession NZ_CP010418
Organism Azotobacter chroococcum NCIMB 8003

Toxin (Protein)


Gene name relE Uniprot ID A0A0C4WUF3
Locus tag Achr_RS20835 Protein ID WP_040107086.1
Coordinates 38007..38288 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0C4WS17
Locus tag Achr_RS20840 Protein ID WP_040107087.1
Coordinates 38275..38535 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Achr_RS20815 33260..35065 + 1806 WP_040107082.1 type I restriction-modification system subunit M -
Achr_RS20820 35062..36195 + 1134 WP_040107083.1 DUF1016 family protein -
Achr_RS20825 36192..37334 + 1143 WP_040107084.1 restriction endonuclease subunit S -
Achr_RS20830 37479..37775 + 297 WP_040107085.1 HU family DNA-binding protein -
Achr_RS20835 38007..38288 - 282 WP_040107086.1 type II toxin-antitoxin system YafQ family toxin Toxin
Achr_RS20840 38275..38535 - 261 WP_040107087.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
Achr_RS20845 38593..39207 - 615 WP_040107088.1 recombinase family protein -
Achr_RS25495 39590..42595 + 3006 WP_144411629.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..62783 62783


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-71)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10819.28 Da        Isoelectric Point: 6.7553

>T52383 WP_040107086.1 NZ_CP010418:c38288-38007 [Azotobacter chroococcum NCIMB 8003]
VRAIKQTSQFKRDLKREAKGQYQATLEDDLMPVLEALAQDHPLDIRHRDHALSGNWKDHRDCHIKPDLVLLYRKPDDETL
ELIRLGSHSELGL

Download         Length: 282 bp

>T52383 NZ_CP010418:c38288-38007 [Azotobacter chroococcum NCIMB 8003]
GTGCGAGCGATTAAGCAAACCAGTCAATTCAAGCGCGACTTGAAACGCGAAGCGAAGGGGCAGTACCAGGCGACGCTCGA
GGATGACTTGATGCCCGTCCTCGAGGCCCTAGCGCAGGATCATCCGCTGGATATACGGCACCGTGATCATGCGCTGTCCG
GTAACTGGAAGGATCACCGTGACTGCCATATCAAGCCGGATCTGGTGCTTCTGTATCGGAAACCGGACGACGAAACGCTG
GAGCTGATTCGCCTCGGCTCGCATAGCGAGTTAGGCCTCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9441.88 Da        Isoelectric Point: 4.3895

>AT52383 WP_040107087.1 NZ_CP010418:c38535-38275 [Azotobacter chroococcum NCIMB 8003]
MATDTVVRARVDERVKEEATVVLKSMGLSMTDAIQMMLIRVAEEGRLPFEPLVPSLETIAAAREAREGNLETVTLDDLRA
AIRASD

Download         Length: 261 bp

>AT52383 NZ_CP010418:c38535-38275 [Azotobacter chroococcum NCIMB 8003]
ATGGCTACCGATACGGTCGTGCGCGCCCGCGTGGACGAACGAGTGAAGGAGGAGGCTACCGTTGTGCTCAAATCAATGGG
GCTGTCGATGACGGATGCCATCCAGATGATGCTGATCCGCGTCGCCGAGGAGGGACGGCTCCCGTTCGAGCCGTTGGTGC
CATCCTTGGAAACCATCGCTGCTGCGCGGGAAGCGCGCGAGGGGAACCTCGAAACCGTGACCCTGGACGATCTACGGGCG
GCGATCCGTGCGAGCGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C4WUF3

Antitoxin

Source ID Structure
AlphaFold DB A0A0C4WS17

References