52380

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 2974188..2974703 Replicon chromosome
Accession NZ_CP010415
Organism Azotobacter chroococcum NCIMB 8003

Toxin (Protein)


Gene name relE Uniprot ID A0A0C4WII4
Locus tag Achr_RS13345 Protein ID WP_039805097.1
Coordinates 2974188..2974442 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0C4WNE7
Locus tag Achr_RS13350 Protein ID WP_039805099.1
Coordinates 2974446..2974703 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Achr_RS13325 2970154..2971170 + 1017 WP_039805088.1 AraC family transcriptional regulator -
Achr_RS13330 2971672..2972904 + 1233 WP_039805089.1 MFS transporter -
Achr_RS13335 2972941..2973669 - 729 WP_039805092.1 SIMPL domain-containing protein -
Achr_RS13340 2973817..2974194 + 378 WP_039805094.1 hypothetical protein -
Achr_RS13345 2974188..2974442 - 255 WP_039805097.1 Txe/YoeB family addiction module toxin Toxin
Achr_RS13350 2974446..2974703 - 258 WP_039805099.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
Achr_RS13355 2974933..2976138 - 1206 WP_039805101.1 MFS transporter -
Achr_RS13360 2976182..2976595 - 414 WP_039805103.1 MarR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9990.42 Da        Isoelectric Point: 8.0486

>T52380 WP_039805097.1 NZ_CP010415:c2974442-2974188 [Azotobacter chroococcum NCIMB 8003]
MNILFTPEAWDDYLWFQQNDKAGLKRINLLIRDAQRDPFGGLGKPEPLKHNLSGFWSRRIGEEHRLVYRVDGDALQIVMC
RYHY

Download         Length: 255 bp

>T52380 NZ_CP010415:c2974442-2974188 [Azotobacter chroococcum NCIMB 8003]
TTGAACATTCTCTTCACGCCCGAGGCCTGGGACGACTACCTGTGGTTCCAGCAGAACGACAAGGCTGGGCTCAAGCGGAT
CAACCTGCTGATCCGGGATGCGCAACGCGATCCGTTCGGTGGTCTTGGCAAGCCGGAGCCGTTGAAGCACAACCTCAGCG
GTTTCTGGTCACGCCGCATCGGCGAGGAGCACCGGCTGGTCTACAGGGTGGACGGAGATGCTCTGCAGATCGTGATGTGC
CGTTATCACTACTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9570.84 Da        Isoelectric Point: 5.8234

>AT52380 WP_039805099.1 NZ_CP010415:c2974703-2974446 [Azotobacter chroococcum NCIMB 8003]
MQTINYTTARQHLAETMDRVNNDRTPILVTRQKGEPVVMISLADYNALEETAYLLRSPANAERLIRSIASLRAGKAEPRS
LVDED

Download         Length: 258 bp

>AT52380 NZ_CP010415:c2974703-2974446 [Azotobacter chroococcum NCIMB 8003]
ATGCAGACCATCAACTACACCACGGCACGCCAGCATCTGGCGGAAACCATGGATCGGGTGAACAACGACCGCACGCCCAT
CCTAGTCACCCGGCAGAAGGGCGAGCCGGTGGTGATGATTTCCCTGGCCGACTACAACGCTCTCGAGGAGACGGCCTATC
TGCTGCGCTCGCCGGCCAATGCGGAGCGTCTGATCCGCTCGATCGCCAGCCTGCGCGCCGGCAAGGCGGAGCCGCGGTCG
CTCGTCGACGAAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C4WII4

Antitoxin

Source ID Structure
AlphaFold DB A0A0C4WNE7

References