Detailed information of TA system TA052379

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/RHH(antitoxin)
• Location: 2463567..2464120
• Replicon: chromosome
• Accession: NZ_CP010415
• Organism: Azotobacter chroococcum NCIMB 8003

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: Achr_RS11155
• Protein ID: WP_039804326.1
• Coordinates: 2463827..2464120 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0C4WMP9
• Locus tag: Achr_RS11150
• Protein ID: WP_039804324.1
• Coordinates: 2463567..2463839 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Achr_RS11135	2460298..2460843	-	546	WP_039804320.1	hypothetical protein	-
Achr_RS11140	2460849..2461199	-	351	Protein_2251	virulence RhuM family protein	-
Achr_RS11145	2461829..2463103	+	1275	WP_052263928.1	ATP-binding protein	-
Achr_RS11150	2463567..2463839	+	273	WP_039804324.1	CopG family ribbon-helix-helix protein	Antitoxin
Achr_RS11155	2463827..2464120	+	294	WP_039804326.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Achr_RS11160	2464199..2464480	-	282	WP_039804329.1	hypothetical protein	-
Achr_RS11165	2464587..2464868	+	282	Protein_2256	PIN domain nuclease	-
Achr_RS11170	2464974..2465249	-	276	WP_039804331.1	nucleotidyltransferase family protein	-
Achr_RS11175	2465317..2466132	-	816	WP_039804333.1	IS5 family transposase	-
Achr_RS11180	2466290..2467609	+	1320	WP_082045557.1	IS4 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2445805..2483037	37232

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-95)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-40)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 10896.41 Da
• Isoelectric Point: 5.1548

>T52379 WP_039804326.1 NZ_CP010415:2463827-2464120 [Azotobacter chroococcum NCIMB 8003]
VPRVVVTEGAAQGLERYRLFLAEKSPQVASRAGQAIERQFALLEKSPDIGRPFPELPELRELIIAFGDAGYVALYRYEPA
DDTVYVLAFRHQKEAGY

Nucleotide

• Length: 294 bp

>T52379 NZ_CP010415:2463827-2464120 [Azotobacter chroococcum NCIMB 8003]
GTGCCACGAGTAGTCGTCACCGAAGGTGCAGCACAAGGTTTGGAACGCTATCGCCTGTTCTTGGCTGAGAAAAGCCCGCA
GGTAGCCAGCCGTGCCGGCCAAGCCATTGAGCGTCAGTTCGCCCTCTTGGAGAAAAGCCCGGACATAGGGCGCCCATTTC
CTGAGCTGCCTGAGCTACGCGAGCTGATCATAGCCTTCGGTGACGCTGGCTATGTCGCGCTCTACCGATATGAGCCGGCG
GATGACACCGTGTACGTTTTGGCCTTCCGGCACCAGAAAGAAGCAGGATACTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10611.77 Da
• Isoelectric Point: 5.6230

>AT52379 WP_039804324.1 NZ_CP010415:2463567-2463839 [Azotobacter chroococcum NCIMB 8003]
MATSIKIDDELKARIQHLASQRQRSAHWIMREAIAQYVEREEARESFKQEALASWAAYRETGRHLTGQETREWLNTWGKE
EETAVPECHE

Nucleotide

• Length: 273 bp

>AT52379 NZ_CP010415:2463567-2463839 [Azotobacter chroococcum NCIMB 8003]
ATGGCGACTTCGATTAAAATCGACGATGAATTGAAAGCCCGCATCCAGCATCTGGCCAGCCAGCGGCAGCGCTCGGCCCA
CTGGATCATGCGCGAGGCCATCGCGCAGTACGTCGAGCGCGAGGAGGCTCGCGAGAGCTTCAAGCAGGAGGCTTTGGCCT
CTTGGGCTGCCTACCGGGAAACCGGAAGGCATCTGACGGGCCAAGAAACGCGGGAATGGCTCAACACCTGGGGCAAGGAA
GAAGAAACGGCGGTGCCTGAGTGCCACGAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A0C4WMP9