Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relB-parE/RHH(antitoxin)
Location 2463567..2464120 Replicon chromosome
Accession NZ_CP010415
Organism Azotobacter chroococcum NCIMB 8003

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag Achr_RS11155 Protein ID WP_039804326.1
Coordinates 2463827..2464120 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0C4WMP9
Locus tag Achr_RS11150 Protein ID WP_039804324.1
Coordinates 2463567..2463839 (+) Length 91 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Achr_RS11135 2460298..2460843 - 546 WP_039804320.1 hypothetical protein -
Achr_RS11140 2460849..2461199 - 351 Protein_2251 virulence RhuM family protein -
Achr_RS11145 2461829..2463103 + 1275 WP_052263928.1 ATP-binding protein -
Achr_RS11150 2463567..2463839 + 273 WP_039804324.1 CopG family ribbon-helix-helix protein Antitoxin
Achr_RS11155 2463827..2464120 + 294 WP_039804326.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Achr_RS11160 2464199..2464480 - 282 WP_039804329.1 hypothetical protein -
Achr_RS11165 2464587..2464868 + 282 Protein_2256 PIN domain nuclease -
Achr_RS11170 2464974..2465249 - 276 WP_039804331.1 nucleotidyltransferase family protein -
Achr_RS11175 2465317..2466132 - 816 WP_039804333.1 IS5 family transposase -
Achr_RS11180 2466290..2467609 + 1320 WP_082045557.1 IS4 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2445805..2483037 37232


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 98 a.a.        Molecular weight: 10896.41 Da        Isoelectric Point: 5.1548

>T52379 WP_039804326.1 NZ_CP010415:2463827-2464120 [Azotobacter chroococcum NCIMB 8003]
VPRVVVTEGAAQGLERYRLFLAEKSPQVASRAGQAIERQFALLEKSPDIGRPFPELPELRELIIAFGDAGYVALYRYEPA
DDTVYVLAFRHQKEAGY

Download         Length: 294 bp

>T52379 NZ_CP010415:2463827-2464120 [Azotobacter chroococcum NCIMB 8003]
GTGCCACGAGTAGTCGTCACCGAAGGTGCAGCACAAGGTTTGGAACGCTATCGCCTGTTCTTGGCTGAGAAAAGCCCGCA
GGTAGCCAGCCGTGCCGGCCAAGCCATTGAGCGTCAGTTCGCCCTCTTGGAGAAAAGCCCGGACATAGGGCGCCCATTTC
CTGAGCTGCCTGAGCTACGCGAGCTGATCATAGCCTTCGGTGACGCTGGCTATGTCGCGCTCTACCGATATGAGCCGGCG
GATGACACCGTGTACGTTTTGGCCTTCCGGCACCAGAAAGAAGCAGGATACTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10611.77 Da        Isoelectric Point: 5.6230

>AT52379 WP_039804324.1 NZ_CP010415:2463567-2463839 [Azotobacter chroococcum NCIMB 8003]
MATSIKIDDELKARIQHLASQRQRSAHWIMREAIAQYVEREEARESFKQEALASWAAYRETGRHLTGQETREWLNTWGKE
EETAVPECHE

Download         Length: 273 bp

>AT52379 NZ_CP010415:2463567-2463839 [Azotobacter chroococcum NCIMB 8003]
ATGGCGACTTCGATTAAAATCGACGATGAATTGAAAGCCCGCATCCAGCATCTGGCCAGCCAGCGGCAGCGCTCGGCCCA
CTGGATCATGCGCGAGGCCATCGCGCAGTACGTCGAGCGCGAGGAGGCTCGCGAGAGCTTCAAGCAGGAGGCTTTGGCCT
CTTGGGCTGCCTACCGGGAAACCGGAAGGCATCTGACGGGCCAAGAAACGCGGGAATGGCTCAACACCTGGGGCAAGGAA
GAAGAAACGGCGGTGCCTGAGTGCCACGAGTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0C4WMP9

References