Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YafQ-RelB |
| Location | 2151715..2152281 | Replicon | chromosome |
| Accession | NZ_CP010411 | ||
| Organism | Bifidobacterium longum subsp. infantis strain BT1 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A0L7BQL3 |
| Locus tag | RY67_RS09195 | Protein ID | WP_029680114.1 |
| Coordinates | 2151988..2152281 (+) | Length | 98 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A7U4H5P9 |
| Locus tag | RY67_RS09190 | Protein ID | WP_038425943.1 |
| Coordinates | 2151715..2151984 (+) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| RY67_RS09160 | 2147268..2147681 | - | 414 | WP_158082797.1 | transposase | - |
| RY67_RS12730 | 2147565..2147816 | - | 252 | Protein_1804 | transposase | - |
| RY67_RS09165 | 2148188..2149939 | + | 1752 | WP_012577721.1 | sodium:solute symporter family protein | - |
| RY67_RS09170 | 2149973..2150314 | + | 342 | WP_012577722.1 | hypothetical protein | - |
| RY67_RS12300 | 2150653..2150997 | + | 345 | WP_158082798.1 | hypothetical protein | - |
| RY67_RS09180 | 2150996..2151199 | + | 204 | Protein_1808 | efflux RND transporter periplasmic adaptor subunit | - |
| RY67_RS12735 | 2151196..2151318 | + | 123 | Protein_1809 | ABC transporter ATP-binding protein | - |
| RY67_RS12305 | 2151313..2151478 | + | 166 | Protein_1810 | ABC transporter permease | - |
| RY67_RS09190 | 2151715..2151984 | + | 270 | WP_038425943.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| RY67_RS09195 | 2151988..2152281 | + | 294 | WP_029680114.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
| RY67_RS11805 | 2152338..2152621 | + | 284 | Protein_1813 | hypothetical protein | - |
| RY67_RS09205 | 2152824..2153409 | - | 586 | Protein_1814 | cell filamentation protein Fic | - |
| RY67_RS09210 | 2153406..2153585 | - | 180 | WP_060621639.1 | antitoxin VbhA family protein | - |
| RY67_RS09215 | 2153799..2154440 | + | 642 | WP_060621067.1 | hypothetical protein | - |
| RY67_RS09220 | 2154580..2154873 | + | 294 | WP_012471870.1 | hypothetical protein | - |
| RY67_RS09225 | 2154897..2155358 | + | 462 | WP_019727563.1 | HipA N-terminal domain-containing protein | - |
| RY67_RS12620 | 2155522..2155773 | - | 252 | WP_082248201.1 | hypothetical protein | - |
| RY67_RS12315 | 2156104..2156442 | + | 339 | Protein_1820 | MFS transporter | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2146647..2166638 | 19991 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 98 a.a. Molecular weight: 11160.90 Da Isoelectric Point: 9.7881
>T52368 WP_029680114.1 NZ_CP010411:2151988-2152281 [Bifidobacterium longum subsp. infantis]
MLKPDYTAAFQRDIKKLKRKHADLRPLKEVIRLVLEDTADSKEALRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELLGK
MLKPDYTAAFQRDIKKLKRKHADLRPLKEVIRLVLEDTADSKEALRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELLGK
Download Length: 294 bp
>T52368 NZ_CP010411:2151988-2152281 [Bifidobacterium longum subsp. infantis]
ATGCTCAAACCGGATTACACAGCGGCATTCCAGCGAGATATCAAGAAACTCAAACGCAAGCACGCTGATTTACGCCCGCT
GAAAGAAGTCATTCGTCTGGTGCTTGAGGACACGGCGGACTCCAAGGAAGCATTGAGGCGTAGGCATCGCGCCCACACAC
TTACCGGTGATCTAAACGGCGTACTGGAATGCCACATCGGCAATGCCGGCGACTGGCTGCTTCTATGGATTCGCGATGAT
GGTACCGCCATGTTTATGCGAACCGGCAGCCATGACGAACTGTTGGGCAAATAG
ATGCTCAAACCGGATTACACAGCGGCATTCCAGCGAGATATCAAGAAACTCAAACGCAAGCACGCTGATTTACGCCCGCT
GAAAGAAGTCATTCGTCTGGTGCTTGAGGACACGGCGGACTCCAAGGAAGCATTGAGGCGTAGGCATCGCGCCCACACAC
TTACCGGTGATCTAAACGGCGTACTGGAATGCCACATCGGCAATGCCGGCGACTGGCTGCTTCTATGGATTCGCGATGAT
GGTACCGCCATGTTTATGCGAACCGGCAGCCATGACGAACTGTTGGGCAAATAG
Antitoxin
Download Length: 90 a.a. Molecular weight: 9830.14 Da Isoelectric Point: 5.0790
>AT52368 WP_038425943.1 NZ_CP010411:2151715-2151984 [Bifidobacterium longum subsp. infantis]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVRERRIPLNLSYTTVPPATMEALDEAKNRLADGRPRFNSA
DEMFDSLGI
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVRERRIPLNLSYTTVPPATMEALDEAKNRLADGRPRFNSA
DEMFDSLGI
Download Length: 270 bp
>AT52368 NZ_CP010411:2151715-2151984 [Bifidobacterium longum subsp. infantis]
GTGAGCATGGCATCCGTCACAGTCCGCGTGGATGCGGACACCAAGCAGAAAGCCGCAAACATAGCCGAGGATCTCGGTCT
GGACTTGTCTTCGGTCACCCGCGCCTTCTACAAGCAGATTGTCCGGGAGAGGCGCATTCCCCTAAACCTTTCCTATACGA
CCGTGCCGCCTGCAACCATGGAGGCCCTTGACGAGGCGAAGAACAGGCTCGCCGACGGCCGACCTCGCTTCAACAGTGCC
GATGAGATGTTCGATTCGTTGGGAATCTGA
GTGAGCATGGCATCCGTCACAGTCCGCGTGGATGCGGACACCAAGCAGAAAGCCGCAAACATAGCCGAGGATCTCGGTCT
GGACTTGTCTTCGGTCACCCGCGCCTTCTACAAGCAGATTGTCCGGGAGAGGCGCATTCCCCTAAACCTTTCCTATACGA
CCGTGCCGCCTGCAACCATGGAGGCCCTTGACGAGGCGAAGAACAGGCTCGCCGACGGCCGACCTCGCTTCAACAGTGCC
GATGAGATGTTCGATTCGTTGGGAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0L7BQL3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4H5P9 |