Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/PIN-RelB
Location 1884380..1885233 Replicon chromosome
Accession NZ_CP010411
Organism Bifidobacterium longum subsp. infantis strain BT1

Toxin (Protein)


Gene name relE Uniprot ID A0A0M4MHM8
Locus tag RY67_RS07935 Protein ID WP_060620906.1
Coordinates 1884742..1885233 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0M5KWH0
Locus tag RY67_RS07930 Protein ID WP_060620905.1
Coordinates 1884380..1884742 (+) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RY67_RS07925 1881535..1884234 + 2700 WP_060620904.1 aconitate hydratase AcnA -
RY67_RS07930 1884380..1884742 + 363 WP_060620905.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
RY67_RS07935 1884742..1885233 + 492 WP_060620906.1 PIN domain-containing protein Toxin
RY67_RS07940 1885294..1887399 - 2106 WP_060620907.1 DUF262 domain-containing protein -
RY67_RS07945 1887488..1888129 - 642 WP_013140893.1 GNAT family N-acetyltransferase -
RY67_RS11705 1888170..1888310 - 141 Protein_1562 DNA-binding response regulator -
RY67_RS07950 1888479..1889381 + 903 WP_032745207.1 Bax inhibitor-1/YccA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1817566..1927390 109824


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-141)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-48)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18342.90 Da        Isoelectric Point: 4.5590

>T52367 WP_060620906.1 NZ_CP010411:1884742-1885233 [Bifidobacterium longum subsp. infantis]
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAEAVMELGAKNNVTLLCASLSLKDIAYLSSSAIRREFKPNESEVENFTRGF
LSSRVPWRCIEQVKEMCDIVAVDESTCDRAFSLQKRHRDFEDDLIIVAAQQSGANCVVTSDAELISHFPEYCKTPAEIVA
ALE

Download         Length: 492 bp

>T52367 NZ_CP010411:1884742-1885233 [Bifidobacterium longum subsp. infantis]
ATGACCGACGTTTCCATGCAGCGTATTTTGCTTGATACCAATGTACTGTTGGACTATTTGCTCCATCGCGATGATCACGC
CAAGATGGCGGAAGCGGTTATGGAACTTGGCGCGAAGAACAACGTTACGTTGTTGTGCGCGTCACTGTCGCTGAAGGATA
TCGCATACCTATCATCATCGGCGATTCGTAGGGAATTCAAACCGAATGAATCGGAAGTGGAGAATTTCACTCGCGGCTTT
CTGTCGTCACGGGTGCCATGGCGTTGTATCGAGCAGGTGAAGGAGATGTGTGACATCGTCGCTGTCGATGAGTCGACATG
TGATAGGGCTTTTTCCCTGCAAAAACGGCATCGGGATTTTGAAGATGATCTGATCATCGTTGCCGCGCAACAATCCGGTG
CCAACTGTGTGGTCACATCGGATGCCGAATTAATCAGTCATTTTCCCGAATATTGCAAAACACCGGCTGAAATCGTGGCG
GCGCTGGAATAA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 14034.14 Da        Isoelectric Point: 5.0733

>AT52367 WP_060620905.1 NZ_CP010411:1884380-1884742 [Bifidobacterium longum subsp. infantis]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALEMTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDKMYDEQLDTYYNMKRAD

Download         Length: 363 bp

>AT52367 NZ_CP010411:1884380-1884742 [Bifidobacterium longum subsp. infantis]
ATGACCATGGTCCAAATGAACGTTCGCATTGATGCGAAACTGAAGAACGAGGTCGAAGAAGTCCTCAAGGGCAAAGGCGT
ATCGGTGAGTGACGTAATCCGTTCGCTGTGGTTGTACATCGCCGACCGCAAGGAAGTGCCGGCATTGGAAATGACCGCCG
AAGAGCAAGCCCGCGAGGAGGAAAAGCAGCGCAAGCTGAAACTGATTCGAGAAGGTGCCGGATACGTGCACAAGGAACTG
GTCAAGGCCGGACTGATCTCAGAAGACACCGACCTCATGGAAGGCCTTACCTACAAGCAGTTCCGCGACAAAATGTACGA
CGAGCAACTTGATACGTATTACAACATGAAGAGGGCCGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4MHM8

Antitoxin

Source ID Structure
AlphaFold DB A0A0M5KWH0

References