Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 755605..756170 Replicon chromosome
Accession NZ_CP010411
Organism Bifidobacterium longum subsp. infantis strain BT1

Toxin (Protein)


Gene name relE Uniprot ID A0A0M4LG91
Locus tag RY67_RS03055 Protein ID WP_060620320.1
Coordinates 755605..755895 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B7GSH1
Locus tag RY67_RS03060 Protein ID WP_012576473.1
Coordinates 755892..756170 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RY67_RS03040 751462..753021 - 1560 WP_158082765.1 iron ABC transporter permease -
RY67_RS03045 753116..754156 - 1041 WP_164997087.1 ABC transporter substrate-binding protein -
RY67_RS03050 754313..755194 - 882 WP_082247995.1 MurR/RpiR family transcriptional regulator -
RY67_RS03055 755605..755895 - 291 WP_060620320.1 type II toxin-antitoxin system YafQ family toxin Toxin
RY67_RS03060 755892..756170 - 279 WP_012576473.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
RY67_RS03065 756400..757608 + 1209 WP_060621501.1 IS256 family transposase -
RY67_RS03070 758026..758310 + 285 WP_168796055.1 hypothetical protein -
RY67_RS03075 758315..758851 - 537 WP_129558956.1 transposase -
RY67_RS03080 759050..759694 + 645 WP_060620322.1 hypothetical protein -
RY67_RS03090 760116..760670 - 555 WP_060620323.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 746671..769728 23057
- flank IS/Tn - - 756364..757608 1244


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(6-95)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-70)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10839.54 Da        Isoelectric Point: 9.9591

>T52366 WP_060620320.1 NZ_CP010411:c755895-755605 [Bifidobacterium longum subsp. infantis]
MSGIQYTVKTTSRFRKDFKLARRRGLDAGLFKQVVSILSEGGTLPDRYHDHALTGNMTGFRECHITPDLLLVYLIEKDVL
VLTLTRTGTHSDLFGK

Download         Length: 291 bp

>T52366 NZ_CP010411:c755895-755605 [Bifidobacterium longum subsp. infantis]
ATGAGCGGCATCCAGTACACGGTCAAGACCACGTCCAGATTCAGGAAGGACTTCAAACTCGCCAGACGACGCGGACTGGA
CGCCGGCCTTTTCAAACAGGTTGTATCCATTCTGTCCGAGGGCGGCACACTGCCCGACCGATATCATGACCATGCGCTTA
CAGGCAATATGACCGGCTTCAGGGAGTGCCATATCACACCAGACCTGCTGTTGGTCTATCTCATAGAGAAGGACGTGCTG
GTGCTCACTCTGACCCGAACGGGCACCCATAGTGACCTTTTCGGAAAATAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10202.63 Da        Isoelectric Point: 6.3216

>AT52366 WP_012576473.1 NZ_CP010411:c756170-755892 [Bifidobacterium longum subsp. infantis]
MSGTTTTVNVRMNAELKKQAEELFGELGMNLTTAVNIFIRQSLRQGGIPFNVSLDEPNRETVSAMLEAKRIARDGNVKGY
RDLNALFKDLDA

Download         Length: 279 bp

>AT52366 NZ_CP010411:c756170-755892 [Bifidobacterium longum subsp. infantis]
ATGAGCGGAACGACAACCACCGTCAACGTCCGAATGAACGCTGAGCTGAAAAAACAAGCCGAGGAACTGTTCGGGGAGTT
GGGCATGAACCTGACCACCGCAGTCAACATATTCATCCGCCAATCCCTGCGACAGGGCGGCATACCGTTCAACGTCTCGT
TGGATGAACCGAACAGGGAGACCGTCTCCGCCATGTTGGAGGCGAAGCGAATCGCAAGGGACGGGAACGTGAAAGGCTAC
CGGGACCTGAACGCCTTGTTCAAGGACTTGGACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4LG91

Antitoxin

Source ID Structure
AlphaFold DB A0A0A8MHE5

References