Detailed information of TA system TA052361

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): spoIISABC/SpoIISA-SpoIISB
• Location: 831100..832017
• Replicon: chromosome
• Accession: NZ_CP010406
• Organism: Bacillus sp. Pc3

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: I2HQ15
• Locus tag: SB24_RS03365
• Protein ID: WP_007407256.1
• Coordinates: 831100..831846 (+)
• Length: 249 a.a.

Antitoxin (Protein)

• Gene name: spoIISB
• Uniprot ID: I2HQ14
• Locus tag: SB24_RS03370
• Protein ID: WP_003154807.1
• Coordinates: 831847..832017 (+)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SB24_RS03345	826493..827443	-	951	WP_039251754.1	ring-cleaving dioxygenase	-
SB24_RS03350	827766..829082	+	1317	WP_007610842.1	amino acid permease	-
SB24_RS03355	829368..829985	+	618	WP_003154804.1	DUF47 domain-containing protein	-
SB24_RS03360	829998..830996	+	999	WP_003154805.1	inorganic phosphate transporter	-
SB24_RS03365	831100..831846	+	747	WP_007407256.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
SB24_RS03370	831847..832017	+	171	WP_003154807.1	type II toxin-antitoxin system SpoIISB family antitoxin	Antitoxin
SB24_RS03375	832286..833152	-	867	WP_039251757.1	N-acetylmuramoyl-L-alanine amidase	-
SB24_RS03380	833166..833429	-	264	WP_003154813.1	phage holin	-
SB24_RS03385	833443..833706	-	264	WP_003154815.1	hemolysin XhlA family protein	-
SB24_RS03390	833758..834519	-	762	WP_033575307.1	hypothetical protein	-
SB24_RS03395	834576..834773	-	198	WP_012117366.1	XkdX family protein	-
SB24_RS03400	834778..835149	-	372	WP_015417295.1	YomQ/XkdW protein, phage-like element PBSX	-
SB24_RS03405	835162..836793	-	1632	WP_015417294.1	pyocin knob domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (3-239)

Antitoxin

• Antitoxin SpoIISB (1-56)

Sequences

Toxin

Protein

• Length: 249 a.a.
• Molecular weight: 29077.57 Da
• Isoelectric Point: 4.7755

>T52361 WP_007407256.1 NZ_CP010406:831100-831846 [Bacillus sp. Pc3]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Nucleotide

• Length: 747 bp

>T52361 NZ_CP010406:831100-831846 [Bacillus sp. Pc3]
ATGCTTTTGTTTTTTCAGATTATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
GGCAAAGGTAAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTACTGGGCTCCATGGTCTATTGGA
CATATGATCCCGAATCGCTCTTTGCCGCATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCAGCAGACTGCTGGCCGCTTATGCCGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAATCGGATAAGGACCGCTTGACGGAGCATATGCCTGATGCGGCGGACGTTCAGTCCCGTCTTAA
CCGTAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAGAACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6676.74 Da
• Isoelectric Point: 10.9273

>AT52361 WP_003154807.1 NZ_CP010406:831847-832017 [Bacillus sp. Pc3]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Nucleotide

• Length: 171 bp

>AT52361 NZ_CP010406:831847-832017 [Bacillus sp. Pc3]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA

Structures

Toxin

• AlphaFold DB: I2HQ15

Antitoxin

• AlphaFold DB: I2HQ14