Detailed information of TA system TA052347

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_XRE(antitoxin)
• Location: 1546297..1547094
• Replicon: chromosome
• Accession: NZ_CP010402
• Organism: Staphylococcus aureus strain GR2

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A641AAS6
• Locus tag: RT44_RS07545
• Protein ID: WP_000525006.1
• Coordinates: 1546633..1547094 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: RT44_RS07540
• Protein ID: WP_001260486.1
• Coordinates: 1546297..1546620 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RT44_RS07490	1542032..1542589	-	558	WP_000645042.1	DUF2815 family protein	-
RT44_RS07495	1542615..1543781	-	1167	WP_000762551.1	DUF2800 domain-containing protein	-
RT44_RS07500	1543778..1544140	-	363	WP_000279446.1	hypothetical protein	-
RT44_RS07505	1544155..1544478	-	324	WP_000175000.1	hypothetical protein	-
RT44_RS07510	1544558..1544719	-	162	WP_001285955.1	DUF1270 family protein	-
RT44_RS07515	1544732..1544995	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
RT44_RS07520	1545020..1545235	-	216	WP_001036301.1	hypothetical protein	-
RT44_RS07525	1545290..1545655	+	366	WP_001128433.1	hypothetical protein	-
RT44_RS07530	1545624..1545869	-	246	WP_001025401.1	DUF2829 domain-containing protein	-
RT44_RS07535	1545885..1546133	-	249	WP_000272861.1	helix-turn-helix domain-containing protein	-
RT44_RS07540	1546297..1546620	+	324	WP_001260486.1	helix-turn-helix domain-containing protein	Antitoxin
RT44_RS07545	1546633..1547094	+	462	WP_000525006.1	hypothetical protein	Toxin
RT44_RS07550	1547111..1547545	+	435	WP_001226136.1	hypothetical protein	-
RT44_RS07555	1547574..1547969	+	396	WP_000449655.1	hypothetical protein	-
RT44_RS07560	1548059..1548205	+	147	WP_001013104.1	hypothetical protein	-
RT44_RS07565	1548202..1548816	-	615	WP_000191459.1	hypothetical protein	-
RT44_RS14660	1548942..1550148	+	1207	Protein_1452	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukF-PV / lukS-PV	1504696..1569522	64826

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (8-65)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 18118.47 Da
• Isoelectric Point: 4.6915

>T52347 WP_000525006.1 NZ_CP010402:1546633-1547094 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVYRYKEI

Nucleotide

• Length: 462 bp

>T52347 NZ_CP010402:1546633-1547094 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTATCGATACAAAGAGATATAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12427.10 Da
• Isoelectric Point: 9.3811

>AT52347 WP_001260486.1 NZ_CP010402:1546297-1546620 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Nucleotide

• Length: 324 bp

>AT52347 NZ_CP010402:1546297-1546620 [Staphylococcus aureus]
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAAAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATACGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAAA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAACCAGAAAACGAAGTACAACATCGTGCA
GCTCACCTTGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA

Structures

Toxin

• AlphaFold DB: A0A641AAS6