52343

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 844653..845130 Replicon chromosome
Accession NZ_CP010402
Organism Staphylococcus aureus strain GR2

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag RT44_RS04065 Protein ID WP_000052076.1
Coordinates 844653..844841 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag RT44_RS04070 Protein ID WP_001059690.1
Coordinates 844870..845130 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RT44_RS04035 840695..841165 + 471 WP_000824472.1 hypothetical protein -
RT44_RS04040 841506..842192 + 687 WP_001566557.1 thermonuclease family protein -
RT44_RS04045 842549..842749 + 201 WP_001059082.1 cold-shock protein -
RT44_RS04050 843244..843462 - 219 WP_000005884.1 hypothetical protein -
RT44_RS04055 843524..843808 - 285 WP_001004394.1 hypothetical protein -
RT44_RS04060 843896..844465 - 570 WP_001106652.1 hypothetical protein -
RT44_RS04065 844653..844841 - 189 WP_000052076.1 hypothetical protein Toxin
RT44_RS04070 844870..845130 - 261 WP_001059690.1 hypothetical protein Antitoxin
RT44_RS04075 845471..845674 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
RT44_RS04080 845671..845907 - 237 WP_000368687.1 hypothetical protein -
RT44_RS04085 846132..846713 + 582 WP_001140697.1 phosphoglycerate mutase family protein -
RT44_RS04090 846786..847403 - 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
RT44_RS04095 847559..848053 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
RT44_RS04100 848452..848874 - 423 WP_000974465.1 organic hydroperoxide resistance protein -
RT44_RS04105 849022..849738 + 717 WP_000150020.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T52343 WP_000052076.1 NZ_CP010402:c844841-844653 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T52343 NZ_CP010402:c844841-844653 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT52343 WP_001059690.1 NZ_CP010402:c845130-844870 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT52343 NZ_CP010402:c845130-844870 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References