Detailed information of TA system TA052342

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pemIK/PRK09812-MazE
• Location: 735739..736328
• Replicon: chromosome
• Accession: NZ_CP010401
• Organism: Bartonella ancashensis strain 20.00

Toxin (Protein)

• Gene name: pemK
• Uniprot ID: A0A0M3T2V4
• Locus tag: PU02_RS03240
• Protein ID: WP_053944049.1
• Coordinates: 735739..736071 (-)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: pemI
• Uniprot ID: -
• Locus tag: PU02_RS03245
• Protein ID: WP_042994729.1
• Coordinates: 736071..736328 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PU02_RS03190	730905..731324	+	420	Protein_614	hypothetical protein	-
PU02_RS03195	731374..731649	+	276	WP_053944643.1	hypothetical protein	-
PU02_RS03200	731865..732182	+	318	WP_053944001.1	hypothetical protein	-
PU02_RS03205	732307..732915	-	609	WP_053944002.1	XRE family transcriptional regulator	-
PU02_RS03210	733292..733615	+	324	Protein_618	type II toxin-antitoxin system HicB family antitoxin	-
PU02_RS03215	733784..734035	+	252	WP_053944046.1	DNA-binding protein	-
PU02_RS03220	734032..734430	+	399	WP_053944047.1	type II toxin-antitoxin system VapC family toxin	-
PU02_RS03225	734595..734900	+	306	WP_053944048.1	hypothetical protein	-
PU02_RS03235	734942..735445	+	504	WP_200903949.1	hypothetical protein	-
PU02_RS03240	735739..736071	-	333	WP_053944049.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
PU02_RS03245	736071..736328	-	258	WP_042994729.1	antitoxin	Antitoxin
PU02_RS03250	736405..736599	-	195	Protein_625	hypothetical protein	-
PU02_RS03260	737375..737821	+	447	WP_053944004.1	single-stranded DNA-binding protein	-
PU02_RS03265	737836..738429	+	594	WP_053944051.1	hypothetical protein	-
PU02_RS03270	738432..738818	+	387	WP_053944052.1	type II toxin-antitoxin system PemK/MazF family toxin	-
PU02_RS03275	739169..739375	+	207	WP_144417854.1	hypothetical protein	-
PU02_RS06835	739454..739615	+	162	WP_158404007.1	hypothetical protein	-
PU02_RS03280	739717..740139	+	423	WP_053943603.1	type II toxin-antitoxin system VapC family toxin	-
PU02_RS06575	740652..740888	+	237	Protein_632	antitoxin MazE family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-109)

Antitoxin

• Antitoxin PemI-like (5-84)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 11936.95 Da
• Isoelectric Point: 10.6585

>T52342 WP_053944049.1 NZ_CP010401:c736071-735739 [Bartonella ancashensis]
MKRGEIWFVSLDPTSGYERKGMRPVLIVSPEAFNHVTKTPIVLPITSGGNFARTAGFAVSLMGSGLRTTGIIRCDQPRAL
DIGTRNGKRMETVSSVIMDEVLAKLSTLLT

Nucleotide

• Length: 333 bp

>T52342 NZ_CP010401:c736071-735739 [Bartonella ancashensis]
ATGAAACGAGGTGAGATCTGGTTTGTTTCGCTTGATCCAACGTCTGGTTATGAGCGAAAAGGAATGCGTCCAGTATTGAT
TGTATCACCTGAGGCGTTTAATCATGTCACAAAGACACCAATTGTTTTACCGATTACAAGTGGAGGGAACTTCGCTAGAA
CAGCAGGTTTTGCTGTTTCATTAATGGGAAGTGGATTGCGTACAACGGGTATTATACGCTGTGATCAACCCCGGGCCTTG
GATATAGGAACACGCAACGGAAAAAGAATGGAAACCGTCTCCTCTGTGATTATGGATGAAGTTTTAGCAAAGCTATCAAC
GTTGCTGACTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9523.87 Da
• Isoelectric Point: 4.0193

>AT52342 WP_042994729.1 NZ_CP010401:c736328-736071 [Bartonella ancashensis]
MHTTKLRKVGGSVMLSIPPALLDVLNLVENTEVDLAIDNGRLIVQPQTHPNYTLDELLAQCDPLADFDDEEMQWLNSQPI
GRELL

Nucleotide

• Length: 258 bp

>AT52342 NZ_CP010401:c736328-736071 [Bartonella ancashensis]
ATGCATACAACAAAGTTACGTAAAGTTGGAGGCTCAGTAATGCTTTCAATACCGCCTGCATTGCTTGATGTCCTCAACCT
GGTTGAAAATACCGAAGTAGATTTAGCCATTGATAATGGCCGTTTGATTGTGCAGCCACAAACCCATCCAAATTATACTC
TTGATGAGCTATTAGCTCAATGTGATCCTTTAGCGGATTTCGATGATGAAGAGATGCAATGGCTTAATTCTCAGCCTATT
GGTAGAGAGCTGTTGTAA

Structures

Toxin

• AlphaFold DB: A0A0M3T2V4