Detailed information of TA system TA052341

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 678453..678933
• Replicon: chromosome
• Accession: NZ_CP010401
• Organism: Bartonella ancashensis strain 20.00

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0M4L7X0
• Locus tag: PU02_RS02940
• Protein ID: WP_053944008.1
• Coordinates: 678453..678722 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A0M4LJF4
• Locus tag: PU02_RS02945
• Protein ID: WP_053944009.1
• Coordinates: 678706..678933 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PU02_RS02900	673822..674430	-	609	WP_053944002.1	XRE family transcriptional regulator	-
PU02_RS02905	674820..675173	-	354	WP_053944003.1	helix-turn-helix transcriptional regulator	-
PU02_RS02910	675514..675807	+	294	WP_053944644.1	hypothetical protein	-
PU02_RS02920	676454..676900	+	447	WP_053944004.1	single-stranded DNA-binding protein	-
PU02_RS02925	676915..677292	+	378	WP_053944005.1	hypothetical protein	-
PU02_RS02930	677357..677608	+	252	WP_144417872.1	type II toxin-antitoxin system VapB family antitoxin	-
PU02_RS02935	677609..678031	+	423	WP_053944007.1	type II toxin-antitoxin system VapC family toxin	-
PU02_RS02940	678453..678722	-	270	WP_053944008.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PU02_RS02945	678706..678933	-	228	WP_053944009.1	ribbon-helix-helix protein, CopG family	Antitoxin
PU02_RS02950	679325..679591	+	267	WP_053944010.1	hypothetical protein	-
PU02_RS02955	680327..681055	+	729	WP_053944011.1	phage regulatory protein/antirepressor Ant	-
PU02_RS02960	681052..681306	+	255	WP_053944012.1	hypothetical protein	-
PU02_RS06550	681414..681738	-	325	Protein_570	HigA family addiction module antidote protein	-
PU02_RS06555	681771..681977	-	207	WP_071628361.1	type II toxin-antitoxin system RelE/ParE family toxin	-
PU02_RS02965	682115..682777	+	663	Protein_572	glycoside hydrolase family protein	-
PU02_RS02970	682774..682983	+	210	WP_053944013.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10557.46 Da
• Isoelectric Point: 10.4099

>T52341 WP_053944008.1 NZ_CP010401:c678722-678453 [Bartonella ancashensis]
MVWTIKYENKALSFLKRCDKKEAQRILNFLDEQISPLGNVRTVGKPLRGQLSGLWRYRIGNYRILCDIYDKELFILVLAI
GHRKNIYKN

Nucleotide

• Length: 270 bp

>T52341 NZ_CP010401:c678722-678453 [Bartonella ancashensis]
TTGGTTTGGACGATTAAATATGAAAATAAAGCTCTCAGTTTTTTAAAAAGATGCGACAAAAAAGAAGCACAGCGCATTCT
TAATTTTTTAGATGAACAAATTTCTCCTCTTGGGAATGTGCGTACTGTTGGCAAGCCTTTAAGAGGCCAATTGTCAGGTT
TGTGGAGATATCGTATAGGCAACTACAGGATATTGTGTGATATTTATGACAAAGAACTCTTCATATTAGTTTTAGCTATT
GGACATAGGAAAAATATCTATAAAAATTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8760.79 Da
• Isoelectric Point: 4.6820

>AT52341 WP_053944009.1 NZ_CP010401:c678933-678706 [Bartonella ancashensis]
MTTSIRLPSDLETRLKNLADKTGRTKSFYLREIIERGLEEAEDYYLASQVRERIQKGDATFYSSEEIRKELGLDD

Nucleotide

• Length: 228 bp

>AT52341 NZ_CP010401:c678933-678706 [Bartonella ancashensis]
ATGACGACATCTATTCGGTTGCCAAGCGATCTTGAGACACGTTTAAAAAATCTAGCAGACAAAACAGGACGGACAAAATC
TTTTTATCTGCGTGAAATCATTGAACGTGGGCTCGAAGAAGCAGAAGATTATTATTTAGCTTCTCAAGTAAGAGAACGTA
TACAAAAGGGAGACGCCACTTTTTATAGCTCTGAGGAAATAAGGAAAGAGCTTGGTTTGGACGATTAA

Structures

Toxin

• AlphaFold DB: A0A0M4L7X0

Antitoxin

• AlphaFold DB: A0A0M4LJF4