Detailed information of TA system TA052337

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2667216..2667895
• Replicon: chromosome
• Accession: NZ_CP010397
• Organism: Acinetobacter baumannii strain 6200

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: RU84_RS12325
• Protein ID: WP_000838146.1
• Coordinates: 2667713..2667895 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: RU84_RS12320
• Protein ID: WP_000966688.1
• Coordinates: 2667216..2667620 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RU84_RS12310	2666172..2666435	-	264	WP_001275792.1	hypothetical protein	-
RU84_RS12315	2666437..2667117	-	681	WP_000721572.1	hypothetical protein	-
RU84_RS12320	2667216..2667620	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
RU84_RS12325	2667713..2667895	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
RU84_RS12330	2668221..2668736	-	516	WP_001185592.1	hypothetical protein	-
RU84_RS12335	2668806..2669723	-	918	WP_000094273.1	hypothetical protein	-
RU84_RS12340	2669776..2670747	-	972	WP_032051761.1	hypothetical protein	-
RU84_RS12345	2670747..2671100	-	354	WP_032051762.1	hypothetical protein	-
RU84_RS12350	2671196..2671414	-	219	WP_002002228.1	hypothetical protein	-
RU84_RS12355	2671416..2671814	-	399	WP_002062850.1	hypothetical protein	-
RU84_RS12360	2671816..2672184	-	369	WP_001993865.1	hypothetical protein	-
RU84_RS12365	2672156..2672560	-	405	WP_000247952.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2646494..2696896	50402

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T52337 WP_000838146.1 NZ_CP010397:c2667895-2667713 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T52337 NZ_CP010397:c2667895-2667713 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT52337 WP_000966688.1 NZ_CP010397:c2667620-2667216 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT52337 NZ_CP010397:c2667620-2667216 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6