Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3536446..3537051 Replicon chromosome
Accession NZ_CP010384
Organism Enterobacter hormaechei subsp. xiangfangensis strain 34399

Toxin (Protein)


Gene name hicA Uniprot ID D2TUP9
Locus tag LI66_RS16920 Protein ID WP_012906750.1
Coordinates 3536446..3536625 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A822X3T2
Locus tag LI66_RS16925 Protein ID WP_032619507.1
Coordinates 3536647..3537051 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LI66_RS16890 3531657..3532094 - 438 WP_003863117.1 type II toxin-antitoxin system RatA family toxin -
LI66_RS16895 3532251..3532733 + 483 WP_003863115.1 SsrA-binding protein SmpB -
LI66_RS16900 3533476..3534681 + 1206 WP_039269032.1 DUF4236 domain-containing protein -
LI66_RS16905 3534937..3535608 + 672 WP_039269186.1 SOS response-associated peptidase -
LI66_RS16910 3535618..3535935 - 318 WP_039269033.1 hypothetical protein -
LI66_RS16920 3536446..3536625 + 180 WP_012906750.1 type II toxin-antitoxin system HicA family toxin Toxin
LI66_RS16925 3536647..3537051 + 405 WP_032619507.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LI66_RS16930 3537092..3538162 - 1071 WP_039269035.1 glycosyltransferase family 9 protein -
LI66_RS16935 3538239..3538817 - 579 WP_039269037.1 tail fiber assembly protein -
LI66_RS24450 3538817..3540994 - 2178 WP_052255160.1 phage tail protein -
LI66_RS16945 3540997..3541548 - 552 WP_032619504.1 phage tail protein I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3534937..3576432 41495


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6644.85 Da        Isoelectric Point: 10.9132

>T52313 WP_012906750.1 NZ_CP010384:3536446-3536625 [Enterobacter hormaechei subsp. xiangfangensis]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Download         Length: 180 bp

>T52313 NZ_CP010384:3536446-3536625 [Enterobacter hormaechei subsp. xiangfangensis]
ATGGATAGCAGGAATGCAATAGCAATGATAGAAGCCGATGGGTGGTATCTGGTGAGAGTTAAAGGCAGTCATCACCAGTT
CAAACACCCAACGAAAAAGGGGCTGGTAACGGTAAAGCATCCACAGAAAGACATACCGTTACCGACACTGAAAAGCATCA
AAAAACAGGCGGGGCTCTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14676.53 Da        Isoelectric Point: 4.2136

>AT52313 WP_032619507.1 NZ_CP010384:3536647-3537051 [Enterobacter hormaechei subsp. xiangfangensis]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGEDYQDAIESVREAIEAHIELLVEDGESVPEATTVENWLSDPEYAGAVWALVD
VDITRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVINQR

Download         Length: 405 bp

>AT52313 NZ_CP010384:3536647-3537051 [Enterobacter hormaechei subsp. xiangfangensis]
ATGTTGTACCCTGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTACCTGATATTCCTGGCTGCTTCTCTGG
CGGTGAAGATTATCAGGACGCGATCGAAAGCGTACGTGAAGCGATCGAGGCACACATCGAATTACTGGTTGAAGATGGCG
AGAGCGTTCCCGAAGCAACGACCGTCGAAAACTGGCTATCTGATCCGGAGTACGCCGGTGCGGTATGGGCCCTAGTTGAC
GTGGATATAACACGCCTGATGGGAAAAGCGGAAAAAATCAATGTGACGCTACCCTCATTACTGATCCGACGTATTGATCA
GTTTGTGGCCGCGCATCCTGAATATGGAAGCCGTTCGGGCTTCCTTTCTCGCGTCGCTGCTGACAAGGTTATTAATCAAC
GATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6XDK4

Antitoxin

Source ID Structure
AlphaFold DB A0A822X3T2

References