Detailed information of TA system TA052298

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 126884..127764
• Replicon: plasmid p34983-328.905kb
• Accession: NZ_CP010380
• Organism: Enterobacter hormaechei subsp. hormaechei strain 34983

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LI64_RS23180
• Protein ID: WP_040115187.1
• Coordinates: 127327..127764 (+)
• Length: 146 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LI64_RS23175
• Protein ID: WP_022652121.1
• Coordinates: 126884..127330 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LI64_RS23140	122376..122753	+	378	WP_015063074.1	hypothetical protein	-
LI64_RS23145	122889..123323	+	435	WP_015063073.1	hypothetical protein	-
LI64_RS23150	123324..123644	+	321	WP_077258061.1	hypothetical protein	-
LI64_RS23155	123760..124395	+	636	WP_015063032.1	hypothetical protein	-
LI64_RS23160	124457..125068	+	612	WP_022652124.1	hypothetical protein	-
LI64_RS23165	125055..126323	+	1269	WP_015063031.1	site-specific DNA-methyltransferase	-
LI64_RS23170	126499..126807	+	309	WP_022652122.1	hypothetical protein	-
LI64_RS23175	126884..127330	+	447	WP_022652121.1	DUF2384 domain-containing protein	Antitoxin
LI64_RS23180	127327..127764	+	438	WP_040115187.1	RES family NAD+ phosphorylase	Toxin
LI64_RS23185	127823..128053	+	231	WP_040115188.1	hypothetical protein	-
LI64_RS23190	128388..128720	+	333	WP_022652118.1	hypothetical protein	-
LI64_RS23195	128777..129040	+	264	WP_040115189.1	hypothetical protein	-
LI64_RS23200	129270..130076	+	807	WP_015063028.1	hypothetical protein	-
LI64_RS23205	130123..130569	+	447	WP_015063027.1	hypothetical protein	-
LI64_RS23210	130747..131694	+	948	Protein_124	phosphoadenosine phosphosulfate reductase family protein	-
LI64_RS23215	131830..132465	-	636	WP_012477419.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..328905	328905

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-142)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (95-145)

Sequences

Toxin

Protein

• Length: 146 a.a.
• Molecular weight: 15853.12 Da
• Isoelectric Point: 4.3176

>T52298 WP_040115187.1 NZ_CP010380:127327-127764 [Enterobacter hormaechei subsp. hormaechei]
VILYRMTKTRYITTAWSGLGAKEAGGRWNSVGTALVYLSETASLTMLETLVHINAPQLLDAYTLLSIDVPDDQIQAFDLN
LLPPGWASEDAPAELALYGDNWAESGSSVALRIPSALSPVEFNYLLNPAHPAIFDLMKTVQKIPY

Nucleotide

• Length: 438 bp

>T52298 NZ_CP010380:127327-127764 [Enterobacter hormaechei subsp. hormaechei]
GTGATCCTGTATCGGATGACCAAGACCCGCTATATTACGACTGCATGGTCGGGATTAGGTGCGAAAGAAGCGGGAGGCCG
CTGGAACAGTGTCGGCACAGCACTTGTCTATCTGTCCGAGACGGCCTCTCTGACCATGCTGGAGACGCTGGTGCATATCA
ATGCCCCGCAGCTTCTGGACGCTTACACGCTGCTGAGCATTGATGTCCCGGATGACCAGATCCAGGCCTTTGACTTGAAC
CTGCTGCCGCCGGGCTGGGCAAGTGAAGATGCGCCCGCAGAACTTGCCCTGTATGGCGATAACTGGGCTGAAAGTGGCTC
TTCTGTTGCCCTGCGTATTCCCAGTGCATTATCTCCGGTGGAGTTTAACTACCTTTTAAATCCGGCTCATCCGGCGATTT
TTGATCTGATGAAAACCGTCCAGAAAATTCCTTACTAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16606.03 Da
• Isoelectric Point: 7.4048

>AT52298 WP_022652121.1 NZ_CP010380:126884-127330 [Enterobacter hormaechei subsp. hormaechei]
MTMKVFSPDLSKMNPHGLWQVVGLDNDGIALMDKISHGLEGKVAHSISEWANITPSELRKMSGIPNTTFNRSVKARFTAD
QSERLVRIIRVIERAVELFEGDKEAAQKWMNEPNRGLSWKTPADVVSSETGALEVMRLITRIEHGVYS

Nucleotide

• Length: 447 bp

>AT52298 NZ_CP010380:126884-127330 [Enterobacter hormaechei subsp. hormaechei]
ATGACTATGAAAGTTTTTTCTCCAGATTTATCCAAAATGAACCCGCACGGCTTATGGCAGGTGGTGGGTCTGGATAATGA
CGGCATTGCGCTGATGGACAAAATTAGCCACGGACTGGAAGGTAAAGTCGCTCATTCCATTTCTGAATGGGCGAACATCA
CGCCGTCGGAACTGCGCAAAATGTCCGGCATTCCGAACACCACCTTCAATCGCAGCGTAAAAGCCCGTTTCACTGCGGAT
CAGAGCGAACGTCTGGTGCGTATTATTCGCGTCATTGAACGGGCTGTAGAGCTGTTCGAAGGCGACAAAGAGGCAGCACA
GAAATGGATGAACGAGCCAAACCGTGGCTTGAGCTGGAAGACTCCGGCAGATGTTGTCTCTTCGGAAACCGGCGCACTCG
AAGTGATGCGCCTGATCACCCGTATTGAACACGGAGTCTATTCGTGA