Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3669186..3669843 Replicon chromosome
Accession NZ_CP010377
Organism Enterobacter hormaechei subsp. hormaechei strain 34983

Toxin (Protein)


Gene name cptA Uniprot ID A0A7T1QL73
Locus tag LI64_RS17370 Protein ID WP_032674037.1
Coordinates 3669186..3669596 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag LI64_RS17375 Protein ID WP_003863437.1
Coordinates 3669577..3669843 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LI64_RS17350 3665184..3666917 - 1734 WP_006811870.1 single-stranded-DNA-specific exonuclease RecJ -
LI64_RS17355 3666923..3667636 - 714 WP_006811871.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LI64_RS17360 3667665..3668561 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
LI64_RS17365 3668663..3669184 + 522 WP_006811872.1 flavodoxin FldB -
LI64_RS17370 3669186..3669596 - 411 WP_032674037.1 protein YgfX Toxin
LI64_RS17375 3669577..3669843 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
LI64_RS17380 3670138..3671118 + 981 WP_006811874.1 tRNA-modifying protein YgfZ -
LI64_RS17385 3671203..3671862 - 660 WP_006811875.1 hemolysin III family protein -
LI64_RS17390 3672129..3672860 + 732 WP_006811877.1 MurR/RpiR family transcriptional regulator -
LI64_RS17395 3672977..3674410 + 1434 WP_006811878.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16292.10 Da        Isoelectric Point: 11.1558

>T52297 WP_032674037.1 NZ_CP010377:c3669596-3669186 [Enterobacter hormaechei subsp. hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMTGTPWMLNTGMMLRLRRVEDNRREHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T52297 NZ_CP010377:c3669596-3669186 [Enterobacter hormaechei subsp. hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
ATTGGTGTTACTGGTGCCGTGGCCACTTAGCTATACCCCGCTGTGGTTGCTATTACTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGACAGGGACGCCGTGGATGCTTAACACGGGGATGATGCTACGGCTGCGACGGGTTGAGGACAATCGTCG
CGAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCAGAGTGGCGTGATCTGCGCCGGTTGATTGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT52297 WP_003863437.1 NZ_CP010377:c3669843-3669577 [Enterobacter hormaechei subsp. hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT52297 NZ_CP010377:c3669843-3669577 [Enterobacter hormaechei subsp. hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAGCTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T1QL73

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References