Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2339542..2340287 Replicon chromosome
Accession NZ_CP010377
Organism Enterobacter hormaechei subsp. hormaechei strain 34983

Toxin (Protein)


Gene name tacT Uniprot ID F5RXF6
Locus tag LI64_RS11245 Protein ID WP_006810665.1
Coordinates 2339796..2340287 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A7T1VGI8
Locus tag LI64_RS11240 Protein ID WP_032673836.1
Coordinates 2339542..2339808 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LI64_RS11220 2335019..2336005 + 987 WP_006810670.1 DUF979 domain-containing protein -
LI64_RS11225 2336015..2337010 + 996 WP_006810669.1 DUF2891 domain-containing protein -
LI64_RS11230 2337031..2338419 - 1389 WP_039273807.1 MFS transporter -
LI64_RS11235 2338548..2339453 + 906 WP_032673837.1 LysR family transcriptional regulator -
LI64_RS11240 2339542..2339808 + 267 WP_032673836.1 DUF1778 domain-containing protein Antitoxin
LI64_RS11245 2339796..2340287 + 492 WP_006810665.1 GNAT family N-acetyltransferase Toxin
LI64_RS11250 2340326..2341324 - 999 WP_006810664.1 haloacid dehalogenase-like hydrolase -
LI64_RS11255 2341321..2342334 - 1014 WP_006810663.1 BatD family protein -
LI64_RS11260 2342331..2343845 - 1515 WP_006810662.1 VWA domain-containing protein -
LI64_RS11265 2343842..2344819 - 978 WP_039273812.1 VWA domain-containing protein -
LI64_RS11270 2344812..2345252 - 441 WP_006810660.1 DUF4381 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17773.46 Da        Isoelectric Point: 9.6044

>T52288 WP_006810665.1 NZ_CP010377:2339796-2340287 [Enterobacter hormaechei subsp. hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGHLRRNM
PDPIPVIVLARLAVDVSLHGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTENAKAFYLHHGFKASQTQERTLFLRLP
QEK

Download         Length: 492 bp

>T52288 NZ_CP010377:2339796-2340287 [Enterobacter hormaechei subsp. hormaechei]
GTGGGACGTGTAACAGCTCCAGAGCCCTTATCCAGTGTTCATCAACTGGCGGAGTTCGTCAGTGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGCCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACATTTGTGGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGTTTTTACTCACTGGCTACCGGCAGCGTTAACCATACGGAAGCGACAGGCCATCTTCGCCGTAACATG
CCGGATCCGATTCCCGTGATTGTACTTGCCCGTCTGGCTGTCGATGTCTCATTACACGGAAATGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTGGCAGAGAATATCGGAGTGAGAGCGATCATGGTTCATGCACTCACTG
AAAACGCCAAAGCTTTCTATCTTCACCACGGTTTTAAAGCATCCCAGACTCAGGAACGAACACTGTTTCTCCGGCTTCCT
CAGGAGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT52288 WP_032673836.1 NZ_CP010377:2339542-2339808 [Enterobacter hormaechei subsp. hormaechei]
MKSDVQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT52288 NZ_CP010377:2339542-2339808 [Enterobacter hormaechei subsp. hormaechei]
ATGAAATCAGATGTTCAACTCAATATCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACAGACTTTATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAACAGTATGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T1VG35

Antitoxin

Source ID Structure
AlphaFold DB A0A7T1VGI8

References