Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1105413..1106033 Replicon chromosome
Accession NZ_CP010377
Organism Enterobacter hormaechei subsp. hormaechei strain 34983

Toxin (Protein)


Gene name Hha Uniprot ID F5RUW8
Locus tag LI64_RS05280 Protein ID WP_001291436.1
Coordinates 1105413..1105631 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag LI64_RS05285 Protein ID WP_006809850.1
Coordinates 1105659..1106033 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LI64_RS05245 1100638..1101444 - 807 WP_032673625.1 nickel/cobalt efflux protein RcnA -
LI64_RS05250 1101579..1101851 + 273 WP_006809855.1 metal-sensing transcriptional repressor -
LI64_RS05255 1101844..1103412 - 1569 WP_006809854.1 EAL domain-containing protein -
LI64_RS05260 1103630..1103890 + 261 WP_006809853.1 type B 50S ribosomal protein L31 -
LI64_RS05265 1103893..1104033 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LI64_RS05270 1104069..1104536 - 468 WP_006809852.1 membrane protein -
LI64_RS05275 1104653..1105204 - 552 WP_006809851.1 maltose O-acetyltransferase -
LI64_RS05280 1105413..1105631 - 219 WP_001291436.1 hemolysin expression modulator Hha Toxin
LI64_RS05285 1105659..1106033 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
LI64_RS05290 1106542..1109688 - 3147 WP_006809849.1 multidrug efflux RND transporter permease subunit -
LI64_RS05295 1109711..1110904 - 1194 WP_006809848.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8597.97 Da        Isoelectric Point: 8.9008

>T52286 WP_001291436.1 NZ_CP010377:c1105631-1105413 [Enterobacter hormaechei subsp. hormaechei]
MSEKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T52286 NZ_CP010377:c1105631-1105413 [Enterobacter hormaechei subsp. hormaechei]
ATGTCTGAAAAACCATTAACGAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACCCTCGAACGTGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCCGCTGACCATCGCCTTGCTGAAC
TGACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTATGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT52286 WP_006809850.1 NZ_CP010377:c1106033-1105659 [Enterobacter hormaechei subsp. hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT52286 NZ_CP010377:c1106033-1105659 [Enterobacter hormaechei subsp. hormaechei]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAATCATGGCTGGGTAAACGATCCAACGTCTGCTATCAATTTACAGCTCAACGAGCTGATTGAGC
ATATCGCTACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACGAATGTCAGCAGAGCAAACCCGGTTAGTCTTTCCTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T1VNQ1

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References